文章摘要
郭锦丽,曲成毅,白帆,马俊红,柴耀凤.酗酒与骨质疏松和股骨头坏死的相关性研究[J].中华流行病学杂志,2013,34(7):732-735
酗酒与骨质疏松和股骨头坏死的相关性研究
Relations between alcoholism and osteoporosis or femoral head necrosis
收稿日期:2012-12-03  出版日期:2014-09-17
DOI:10.3760/cma.j.issn.0254-6450.2013.07.017
中文关键词: 酗酒;股骨头坏死;骨质疏松;酒精依赖性疾患识别测验;酒精依赖程度测试
英文关键词: Alcoholism;Femoral head necrosis;Osteoporosis;The Alcohol Use Disorders Identification Test:The Alcohol Use Disorders Scale
基金项目:
作者单位E-mail
郭锦丽 030001 太原, 山西医科大学第二医院护理部  
曲成毅 山西医科大学第二医院公共卫生学院 quchengyi0012@163.com 
白帆 山西医科大学第二医院研究生学院  
马俊红 山西医科大学第二医院研究生学院  
柴耀凤 山西医科大学第二医院研究生学院  
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中文摘要:
      目的探讨酗酒与股骨头坏死(ANFH)、骨质疏松(oP)的相关性。方法采用病例对照研究, 选取山西医科大学第二医院骨科2011年2-12月门诊、病房就医符合条件的ANFH患者95例、OP患者67例作为病例组和342例创伤骨折患者为对照组, 填写调查表, 明确ANFH、OP的-般相关因素, 并在此三组病例中筛选出长期酗酒的ANFH 18例、OP 11例、创伤骨折患者20例, 进-步进行酒精依赖性疾患识别测验(AuDIT)、酒精依赖程度测试(ADS), 采用方差分析、x2检验、无序多分类logistic回归分析酗酒与ANFH、OP的关系。结果无序多分类logistic回归分析显示, 以创伤骨折患者为对照组, 控制其他因素后, 喜饮酒者患ANFH和OP的危险性是不饮酒者的7.70倍和8.44倍;治疗中使用激素者患ANFH和OP的风险是不使用激素者的78.43倍和22.75倍。依据AUDIT, 酒精性ANFH组100%为危害性饮酒和伤害性饮酒;酒精性OP组54.45%为伤害性饮酒和危害性饮酒;创伤骨折组75%为正常饮酒, 筛选诊断结果的差异有统计学意义(P<0.01)。依据ADS标准, 三组患者评分差异有统计学意义(P=0.03)。结论酗酒与ANFH、OP高度相关。酒精性ANFH是酒精依赖性骨疾病, 酒精性OP为部分酒精依赖性骨疾病。
英文摘要:
      ObjectiveTo explore the relationship of alcoholism between osteoporosis or femoral head necrosis.MethodsIn this case.control study.we selected 95 eligible patients with femoral head necrosis and another 67 cases of osteoporosis as case group.together with 342 patients of fractures from the Second Hospital affiliated to Shanxi Medical College.from February to December 2010, as the control group.Questionnaire was used to collect general information of the patients.Through comparative analysis.related factors of femoral head.osteoporosis were defined.18 patients with alcoholic femoral head necrosis.11patients with alcoholic osteoporosis and 20 patients with fractures were selected from the above said three groups and going through the Alcohol Use Disorders Identification Test(AUDIT)as well as the Alcohol Use Disorders Scale(ADS).Using SPSS 13.0conducted one-way ANOVA(analysis of variance), chi-square test, categorical logistic regression analysis were used for statistical analysis.Results Results from logistic regression analysis showed that the adjusted odds ratio ofhose subiects who liked drinking alcohol had an incidence of femoral head necrosis or osteoporosis as 7.70(95%CI:1.84, 32.30)and 8.44(95%CI:1.70, 41.90), respectively.The risks of using hormone for treating femoral head necrosis or osteoporosis were78.43(95%CI:11.20, 149.05)and 22.75(95%CI:2.59, 100.27)times than those without.Data from the AUDIT showed that:over-dose of alcohol drinking habit existed 100%in the femoral head necrosis group while 54.45%in the osteoporosis group, while 75 percent patients in the fractures group had normal alcohol drinking habit.Statistically significant differences appeared in the three groups(PResultsfrom the ADS showed that there were statistically significant differencesbetween the ADS scores of the three groups(F=3.68, P=0.03).ConclusionAlcohol intake did seem to be highly correlated with the incidence rates of femoral head necrosis or osteoporosis.Alcoh01.related necrosis could be viewed as alcoh01..dependent diseases while alcoho1..related and osteoporosis could panially be recognized as alcoh01.dependent disease.
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