| 蒋安然,李青艳,陈建生,刘爱文,陶兴永,计国平,李迎春.接受抗反转录病毒治疗艾滋病患者脂肪 营养不良影响因素分析[J].中华流行病学杂志,2013,34(10):964-966 |
| 接受抗反转录病毒治疗艾滋病患者脂肪 营养不良影响因素分析 |
| Factors related to HIV-associated iipodystrophy among patients on antiretroviral therapy |
| 收稿日期:2013-04-26 出版日期:2014-10-08 |
| DOI： |
| 中文关键词: 艾滋病|抗反转录病毒治疗|脂肪营养不良 |
| 英文关键词: AIDS|Highly active anti-retroviral therapy|Lipodystrophy |
| 基金项目: |
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| 中文摘要: |
| 目的分析接受抗反转录病毒治疗(AI汀)艾滋病患者脂肪营养不良(LD)情况，探 讨影响LD发生的主要因素。方法2012年5月对261名正在接受ART的艾滋病患者进行问卷调 查，收集人口学、体格测量以及ART相关I临床资料，并评估身体外周部位和中心部位的脂肪变 化。结果261名艾滋病患者中147名出现LD，检出率为56．3％。LD组与非脂肪营养不I曼(NLD) 组在年龄、性别、睡眠质量、体重以及治疗时间方面差异有统计学意义(P<0．05)。多因素logistic 回归分析显示，女性患LD的风险是男性的1．894倍(95％CI：1．075—3．338)；治疗时间每增加1年， 患LD风险增加1．448倍(95％CI：1．267～1．654)；睡眠质量越差的患者越容易发生LD，睡眠质量很 差者患LD的风险是很好者的11．901倍(95％c，：2．701～52．441)。结论LD在接受ART的艾滋病 患者中较常见，性别、治疗时间以及睡眠质量是其主要影响因素。 |
| 英文摘要: |
| Objective To describe the distribution and related risk factors of lipodystrophy (LD)among AIDS patients treated with antiretroviral drugs．Methads A cross．sectional study was performed on 26 l AIDS patients treated with antiretroviral drugs．AU the subjects were followed in the Center for Disease Control and Prevention of two counties in northern mnhui province from May 25 to 30，2012．Data related to demography，physical examination，history of antiretroviral treatment，HIV plasma viral load.and CD4+T eell count were collected．Clinical examination Was based on all assessment ofchanges in face，legs，arms，buaocks(pefipheml sites)，back，chest，neck or abdomen or change in waist size(central sites)as quoted by the clinicians．Results LD Was observed in 147 (56．3％)patientsConclusion．The differences of age，gender，quality of sleep，weight and time oftreatment between LD and non-lipodystrophy(NLD)groups were statistically significant(P |
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