| 孙立梅,李晖,谭小华,方苓,邓爱萍,莫艳玲,何剑峰,柯昌文,林锦炎.2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测[J].中华流行病学杂志,2013,34(10):989-992 |
| 2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测 |
| Epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province，in 2012 |
| 收稿日期:2013-05-23 出版日期:2014-10-08 |
| DOI：10．3760/cma．j．issn．0254—6450．2013．10．011 |
| 中文关键词: 腹泻病|症状监测|轮状病毒|诺如病毒|基因分型 |
| 英文关键词: iarrheal disease|Syndromic surveillance|Rotavirus|Norovirus|Genotype |
| 基金项目:广东省医学科研项目(A2012085) |
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| 中文摘要: |
| 目的探讨广东省<5岁儿童腹泻病流行特征和重点病原监测。方法2012年在 广东省21个地市选择64家医院开展腹泻症状监测，其中14家医院采集<5岁儿童腹泻病粪便标 本，开展霍乱弧菌、志贺菌分离培养及轮状病毒、诺如病毒ELISA、PCR检测。分析52周腹泻病症 状监测数据和1932例<5岁儿童腹泻病重点病原监测结果。结果2012年广东省<5岁儿童腹 泻就诊病例占监测门诊就诊总人次数的O．8％，占监测门诊全年龄组腹泻病例就诊总人次数的 63．5％；以医院为基础报告<5岁儿童感染性腹泻病年发病率为1454．5/10万。全年采集<5岁儿 童腹泻病标本1932份，检测霍乱弧菌均为阴性，宋内志贺菌1例阳性，轮状病毒阳性率为14．1％ (273/1932)，诺如病毒阳性率为16．9％(326/1932)，诺如病毒和轮状病毒合并感染24例(1．2％)。 112份轮状病毒和90份诺如病毒阳性标本测序表明，轮状病毒主要以G1[P8]为主(33．9％)，其 次为G9[P8](25．9％)、G2[P4](12．5％)、G3[P8](9．8％)；诺如病毒以GII．4型为主(76．7％)，并检 出5份G I型和16份GⅡ其他型/变异株，除6月(未开展测序工作)和12月外其余各月均检出 GⅡ．4/2006b型(占50．0％)，GII。4/Sydney 2012变异株于8月首次检出并在12月成为流行优势 株。结论<5岁儿童是广东省腹泻病高危人群，感染的轮状病毒和诺如病毒具有基因多样性。 |
| 英文摘要: |
| Objective To analyze the epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province，in 20 1 2．Methads 64 hospitals in 21 cities were chosen as the diarrheal syndromic surveillance sites，of which 14 hospitals were selected to carry out etiological surveillance among children under 5 years of age，including is01．ion and culture of both V/brio cholera and Shigella as well as nucleic acid detection of rotavirus and norovirus by PCR．Descriptive method was used to analyze data from syndromic and etiological surveillance programs on diarrheal．from 1 932 parents of the children，Results In 2012，the outDatient aRendance rate on diarrheal among children under 5 years was 0．8％．The proportion of diarrheal in children under 5-year-olds was 63．5％，among the total number of diarrheal outrIatients at the outpatient clinics under surveillance program．The morbidity of infectious diarrhea was l 454．5/1 0 million in children under 5 years of age．A total number of l 932 specimens were collected from children under 5 years of age，in the outpatient department．Among these specimens，Vibrio cholera appeared all negative but one was Shigella positive and proved to be Sh．SOD,nei．The positive rates of rotavirus and norovirus were 14．1％(273/1932)and 16．9％(326/1932)．Both rotavirus and norovirus were found in 24 specimens．with a positive rate as 1．2％．11 2 specimens were successfully gene— sequenced for rotavirus．ofwhich 33．9％as G1[P8]genotype，25．9％as G9[P8 J，12．5％as G2lP4 J and 9．8％as G3[P8]respectively．90 specimens were successfully gene-sequenced for norovirus，ofwhich 76．7％as G II．4 genotype．Genetic subtypes of GⅡ．4/2006b，accounted for 50．0％and could be detected around the year except for June and December．New G II．4/Sydney Strain——2012 was first detected in August and became the predominant in December．In addition，5 specimens belonged to G I genotype with other 16 subtypesConclusion Results from our study proved that children under 5 years of age belonged to high-risk group for diarrheal disease in Guangdong province． |
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