文章摘要
孙立梅,李晖,谭小华,方苓,邓爱萍,莫艳玲,何剑峰,柯昌文,林锦炎.2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测[J].中华流行病学杂志,2013,34(10):989-992
2012年广东省5岁以下儿童腹泻病 流行特征及重点病原监测
Epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province,in 2012
收稿日期:2013-05-23  出版日期:2014-10-08
DOI:10.3760/cma.j.issn.0254—6450.2013.10.011
中文关键词: 腹泻病|症状监测|轮状病毒|诺如病毒|基因分型
英文关键词: iarrheal disease|Syndromic surveillance|Rotavirus|Norovirus|Genotype
基金项目:广东省医学科研项目(A2012085)
作者单位E-mail
孙立梅 广东省疾病预防控制中心, 广州 511430  
李晖 广东省疾病预防控制中心, 广州 511430  
谭小华 广东省疾病预防控制中心, 广州 511430  
方苓 广东省疾病预防控制中心, 广州 511430  
邓爱萍 广东省疾病预防控制中心, 广州 511430  
莫艳玲 广东省疾病预防控制中心, 广州 511430  
何剑峰 广东省疾病预防控制中心, 广州 511430  
柯昌文 广东省疾病预防控制中心, 广州 511430  
林锦炎 广东省疾病预防控制中心, 广州 511430 linjyl957@sohu.com 
摘要点击次数: 2609
全文下载次数: 771
中文摘要:
      目的探讨广东省<5岁儿童腹泻病流行特征和重点病原监测。方法2012年在 广东省21个地市选择64家医院开展腹泻症状监测,其中14家医院采集<5岁儿童腹泻病粪便标 本,开展霍乱弧菌、志贺菌分离培养及轮状病毒、诺如病毒ELISA、PCR检测。分析52周腹泻病症 状监测数据和1932例<5岁儿童腹泻病重点病原监测结果结果2012年广东省<5岁儿童腹 泻就诊病例占监测门诊就诊总人次数的O.8%,占监测门诊全年龄组腹泻病例就诊总人次数的 63.5%;以医院为基础报告<5岁儿童感染性腹泻病年发病率为1454.5/10万。全年采集<5岁儿 童腹泻病标本1932份,检测霍乱弧菌均为阴性,宋内志贺菌1例阳性,轮状病毒阳性率为14.1% (273/1932),诺如病毒阳性率为16.9%(326/1932),诺如病毒和轮状病毒合并感染24例(1.2%)。 112份轮状病毒和90份诺如病毒阳性标本测序表明,轮状病毒主要以G1[P8]为主(33.9%),其 次为G9[P8](25.9%)、G2[P4](12.5%)、G3[P8](9.8%);诺如病毒以GII.4型为主(76.7%),并检 出5份G I型和16份GⅡ其他型/变异株,除6月(未开展测序工作)和12月外其余各月均检出 GⅡ.4/2006b型(占50.0%),GII。4/Sydney 2012变异株于8月首次检出并在12月成为流行优势 株。结论<5岁儿童是广东省腹泻病高危人群,感染的轮状病毒和诺如病毒具有基因多样性。
英文摘要:
      Objective To analyze the epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province,in 20 1 2.Methads 64 hospitals in 21 cities were chosen as the diarrheal syndromic surveillance sites,of which 14 hospitals were selected to carry out etiological surveillance among children under 5 years of age,including is01.ion and culture of both V/brio cholera and Shigella as well as nucleic acid detection of rotavirus and norovirus by PCR.Descriptive method was used to analyze data from syndromic and etiological surveillance programs on diarrheal.from 1 932 parents of the children,Results In 2012,the outDatient aRendance rate on diarrheal among children under 5 years was 0.8%.The proportion of diarrheal in children under 5-year-olds was 63.5%,among the total number of diarrheal outrIatients at the outpatient clinics under surveillance program.The morbidity of infectious diarrhea was l 454.5/1 0 million in children under 5 years of age.A total number of l 932 specimens were collected from children under 5 years of age,in the outpatient department.Among these specimens,Vibrio cholera appeared all negative but one was Shigella positive and proved to be Sh.SOD,nei.The positive rates of rotavirus and norovirus were 14.1%(273/1932)and 16.9%(326/1932).Both rotavirus and norovirus were found in 24 specimens.with a positive rate as 1.2%.11 2 specimens were successfully gene— sequenced for rotavirus.ofwhich 33.9%as G1[P8]genotype,25.9%as G9[P8 J,12.5%as G2lP4 J and 9.8%as G3[P8]respectively.90 specimens were successfully gene-sequenced for norovirus,ofwhich 76.7%as G II.4 genotype.Genetic subtypes of GⅡ.4/2006b,accounted for 50.0%and could be detected around the year except for June and December.New G II.4/Sydney Strain——2012 was first detected in August and became the predominant in December.In addition,5 specimens belonged to G I genotype with other 16 subtypesConclusion Results from our study proved that children under 5 years of age belonged to high-risk group for diarrheal disease in Guangdong province.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭