| 黄修鸿,杜建龙,吴纯西,刘义山,包梅芳.220例晚期癌患者居家多模式镇痛服务可行性分析[J].中华流行病学杂志,2013,34(12):1242-1244 |
| 220例晚期癌患者居家多模式镇痛服务可行性分析 |
| Feasibility of multi models targeting home pain alleviation service used on 220 cases withadvanced cancer |
| 收稿日期:2013-09-10 出版日期:2014-10-16 |
| DOI：10.3760/cmaj.issn.0254-6450.2013.012.020 |
| 中文关键词: 镇痛 居家多模式 晚期癌 可行性 |
| 英文关键词: Analgesia Home multi mode Advanced cancer Feasibility |
| 基金项目:浙江省医药卫生一般研究计划课题(2013KYA200) |
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| 中文摘要: |
| 目的 观察晚期癌痛患者居家多模式镇痛服务的可行性及有效性,为临床治疗提供依据。方法 将桐乡市第一医院2010年2月至2013年2月收治的220例家居多模式镇痛治疗患者作为研究对象,人组前均经阿片类制剂治疗,患者随机分为A组(112例)和B组(108例),分别给予不同剂量吗啡和其他药物,观察期采用M.D.安德森症状评估量表(MDASI)评分及疼痛分值。结果 两组患者治疗前后的疼痛评分差值和MDASI评分差值均呈明显的偏态分布。不同用药组间疼痛评分差值的差异均有统计学意义(z=-9.735,Pz=-13.334,P结论 晚期癌痛居家多模式镇痛患者短期镇静治疗具有较好的可行性及有效性,且吗啡联合镇静药对居家晚期癌患者镇痛效果显著优于单用吗啡。 |
| 英文摘要: |
| 0bjeetive To investigate the feasibility and effectiveness of multiple modes Offhome pain alleviation service used for advanced cancer patients to in prove clinical therapy services.Methods The study was involved with 220 patients with advanced cancers to provide them withmultimodal analgesia services at home，from February 2010 to February 2013.Patients in this studyhad been taking both opioid treatmeots.They were randomly devided into two groups with the numberas 1 12 and 108 and were given different doses of morphine or other drugs During the period ofobservation，data was collected under the M.D.Anderson symptom Inventory(MDASI)score andclassification of score on pain.Results Difierences of pain scores in the two groups and the MDASIscore were significant and presented as skewed distribution，Scores on pain score were between groupswere significantly different(Z=-9，735，PZ=-13.334.P<0.001).The average rankings ofgroupsA andBwere respectively 59.87 and l 79.08.Under the use of 0.4 mg of alprazolam.the results could beconsidered to show better improvements in symptomatic patients.Application of 0.4 mg alprazolam onpatients with advanced..cancer-induced·-pain showed a better symptomatic improvement than usingmorphine，Conclusion Patients with advanced cancers receiving multimodal analgesia short—termsedation therapies at home.showed hoth ideal feasibility and good effectiveness.When morphine wascombined used with midazolam at home，a better outcome could be seen ifl pain—releasing on patientswith cancer，than single morphine analgesia was used. |
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