文章摘要
陈秋艳,卜晓青,刘艳,徐娟,孔凡龙,汪桂艳,张永红.白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究[J].中华流行病学杂志,2014,35(10):1151-1154
白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究
A nested case-control study in studying the relationship between interleukin-6,endothelin-1, E-selectin and the risk of cardio-cerebrovascular events
收稿日期:2014-05-22  出版日期:2014-09-15
DOI:10.3760/cma.j.issn.0254-6450.2014.10.017
中文关键词: 心脑血管病;炎症;关联强度;巢式病例对照
英文关键词: Cardio-cerebrovascular diseases;Inflammation;Strength of association;Nested case-control study
基金项目:国家自然科学基金(30972531)
作者单位E-mail
陈秋艳 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室  
卜晓青 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室  
刘艳 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室  
徐娟 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室  
孔凡龙 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室  
汪桂艳 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室
厦门市妇幼保健院预防保健科 
 
张永红 215123 苏州大学医学部公共卫生学院流行病与卫生统计学教研室 yhzhang@suda.edu.cn 
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中文摘要:
      目的 研究白介素6(IL-6)、内皮素1(ET-1)及E选择素(E-selectin)与心脑血管事件发生的关系。方法 在对2 589 名蒙古族人群连续随访10 年的队列研究基础上,采用巢式病例对照研究方法,分析IL-6、ET-1 和E-selectin 与心脑血管事件发生的关系,利用logistic 回归分析方法计算OR 值及其95%CI结果 病例组与对照组的IL-6(7.66 vs. 8.77 pg/ml)、ET-1(0.74 vs. 0.75 pg/ml)和E-selectin(17.96 vs. 18.32 ng/ml)的差异无统计学意义(P>0.05)。logistic分析表明,与IL-6≤23.91 pg/ml 或ET-1≤1.33 pg/ml 或E-selectin≤24.43 ng/ml 者相比,IL-6>23.91 pg/ml 或ET-1>1.33 pg/ml 或E-selectin>24.43 ng/ml 者发生心脑血管事件的多因素调整后的OR 值及其95%CI 分别为0.69(0.41~1.16)、1.10(0.66~1.85)和1.19(0.71~2.00),差异均无统计学意义(P>0.05)。结论 调查人群中基线IL-6、ET-1 及E-selectin 水平与心血管事件危险性无显著关联。
英文摘要:
      Objective To investigate the relationship between interleukin-6(IL-6),endothelin-1 (ET-1),E-selectin and the risk of cardio-cerebrovascular events. Methods Based on a cohort study in which 2 589 Mongolians had been followed up for 10 years,a nested case-control study was carried out to analyze the relationship between IL-6,ET-1,E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio(OR) and 95% confidence intervals(95%CI). Results The average level of IL-6(7.66 vs. 8.77 pg/ml), ET-1(0.74 vs. 0.75 pg/ml)and E-selectin(17.96 vs. 18.32 ng/ml)were not significantly different between the case and the control groups(P>0.05). Data from the logistic regression analysis showed that IL-6,ET-1 and E-selectin were not significantly associated with the risk of cardiocerebrovascular events. The multivariable adjusted ORs(95%CI)on the risk of cardio-cerebrovascular events were 0.69 (0.41-1.16),1.10 (0.66-1.85) and 1.19(0.71-2.00) for the participants with IL-6>23.91 pg/ml ,ET-1>1.33 pg/ml and E-selectin>24.43 ng/ml,respectively,compared with those having IL-6≤23.91 pg/ml ,ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml. Conclusion Data from our study indicated that the levels of IL-6,ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia.
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