文章摘要
姜斌,何耀,左芳,吴蕾,刘庆辉,张丽,周长喜,郑家强,陈肇始,林大庆.心理干预联合药物对吸烟者的戒烟效果评价[J].中华流行病学杂志,2014,35(12):1349-1353
心理干预联合药物对吸烟者的戒烟效果评价
Effectiveness of Varenicline with counseling programs on smoking cessation in a targeted clinical setting in China
收稿日期:2014-09-12  出版日期:2014-12-10
DOI:10.3760/cma.j.issn.0254-6450.2014.12.008
中文关键词: 戒烟;吸烟者;药物和心理干预;观察性研究
英文关键词: Smoking cessation;Smoker;Varenicline and counseling;Observational study
基金项目:国家自然科学基金(81373080); 首都医学发展基金(Z121107001012070); 北京市海淀区科普项目(11kp02006); 英国癌症基金会(C1343/A10155)
作者单位E-mail
姜斌 解放军总医院南楼中医针灸科, 北京 100853  
何耀 老年医学研究所 北京市衰老与相关疾病研究重点实验室, 北京 100853 yhe301@x263.net 
左芳 解放军总医院南楼中医针灸科, 北京 100853  
吴蕾 老年医学研究所 北京市衰老与相关疾病研究重点实验室, 北京 100853  
刘庆辉 南楼呼吸科, 北京 100853  
张丽 南楼康复体疗科, 北京 100853  
周长喜 南楼呼吸科, 北京 100853  
郑家强 英国伯明翰大学  
陈肇始 香港大学护理学院  
林大庆 香港大学公共卫生学院  
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中文摘要:
      目的 评价伐尼克兰在临床实践中对戒烟门诊患者戒烟的有效性.方法 采用前瞻性观察性研究设计,选择符合纳入标准的吸烟者799人,每名患者首诊时进行标准的基线问卷评估,并在第1、第3和第6个月进行随访.由经过培训的医师对每名患者完成面对面的咨询和个体化戒烟干预.接受药物辅助戒烟者定为心理干预联合药物组(n=272),未用药者为单纯心理干预组(n=527).采用意向性分析的统计学方法分析比较两组的7天时点戒烟率、3个月随访时的1个月持续戒烟率和6个月随访时的3个月持续戒烟率.结果 6个月随访时,心理干预联合药物组的7天时点戒烟率显著高于单纯心理干预组(34.6% vs. 23.1%;OR=1.75,95% CI:1.27~2.42;P<0.001),心理干预联合药物组的3个月持续戒烟率也显著高于单纯心理干预组(31.3% vs. 18.2%;OR=2.04,95%CI:1.46~2.86;P<0.001).1和3个月随访时,心理干预联合药物组无论是7天时点戒烟率还是1个月持续戒烟率均高于单纯心理干预组.结论 在真实临床实践的戒烟门诊中,给予戒烟者药物辅助戒烟可有效提高戒烟率.
英文摘要:
      Objective To evaluate the effectiveness of Varenicline for smoking cessation in a community-based smoking-cessation-clinic (SCC) in Chinese smokers. Methods A prospective observational study was conducted in Beijing,China. 799 smokers (762 men and 37 women) were assessed on data gathered from structured questionnaires at baseline and follow up programs at 1,3 and 6 months. Trained physician counselors provided free individual counseling and follow-up interviews with brief counseling for all the subjects. 272 subjects were additionally prescribed Varenicline according to their own choice and reported data were compared to those without Varenicline. Outcomes were self-reported,regarding the 7-day point prevalence on abstinence rate and continuous abstinence rates at 1,3 and 6 month follow-up periods. Results At 6-month and by intention-to-treat,the 7-day point prevalence on abstinence rate with Varenicline and counseling,was significantly higher than the group with counseling only (34.6% versus 23.1%;OR=1.75,95%CI:1.27-2.42;P<0.001). The 3-month continuous abstinence rate at 6 month was higher in the group with Varenicline (31.3% versus 18.2%;OR=2.04,95%CI:1.46-2.86;P<0.001). Varenicline also showed better outcomes at 1 and 3 month follow-up. Conclusion Varenicline prescription in the smoking cessation clinic appeared to be effective that doubled the rates of quitting among Chinese smokers in the practice at a community-based SCC.
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