| 彭瑾瑜,陈曦,贺健梅,郑军,覃碧云,江洋.白细胞介素-28B和平衡性核苷转运载体1基因多态性与HIV/HCV合并感染者HCV自发清除的关系研究[J].中华流行病学杂志,2015,36(4):379-382 |
| 白细胞介素-28B和平衡性核苷转运载体1基因多态性与HIV/HCV合并感染者HCV自发清除的关系研究 |
| Relationship between interleukin 28B, equilibrative nucleoside transporters 1 gene polymorphisms and spontaneous clearance of HCV in HIV/HCV co-infectors |
| 收稿日期:2014-10-09 出版日期:2015-04-04 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.04.018 |
| 中文关键词: 丙型肝炎病毒 人类免疫缺陷病毒 白细胞介素-28B 平衡性核苷转运载体1 自发清除 单核苷酸多态性 |
| 英文关键词: Hepatitis C virus Human immunodeficiency virus Interleukin 28B Equilibrative nucleoside transporters 1 Spontaneous clearance Single nucleotide polymorphism |
| 基金项目:湖南省科技厅课题(2012SK3267) |
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| 中文摘要: |
| 目的 分析湖南省HIV/HCV合并感染者的白细胞介素-28B(IL-28B)和平衡性核苷转运载体1(ENT1)基因多态性与HCV自发清除的关系。方法 对湖南省107例HIV/HCV合并感染者的IL-28B和ENT1基因位点(rs12980275、rs12979860、rs8099917和rs760370)进行分型, 比较其在慢性肝炎组和自发清除组的基因多态性分布。结果 在HIV/HCV合并感染者中, IL-28B基因rs12980275、rs12979860和rs8099917位点的主要基因型分别为AA、CC和TT型, 均占84.1%。3个位点高度连锁不平衡(r2>0.94), 慢性肝炎组和自发清除组基因型分布差异有统计学意义(P<0.05), 携带IL-28B主要基因型的感染者更易发生HCV自发清除。ENT1基因的rs760370位点基因型分布在两组间的差异无统计学意义(P>0.05)。结论 IL-28B基因AA、CC和TT型与HCV自发清除有关。 |
| 英文摘要: |
| Objective To explore the association between interleukin 28B(IL-28B), equilibrative nucleoside transporters 1(ENT1) gene polymorphisms and spontaneous clearance of HCV in HIV/HCV co-infectors in Hunan province. Methods Genotypes of IL-28B and ENT1 (rs12980275, rs12979860, rs8099917 and rs760370) were analyzed in 107 HIV/HCV co-infectors in Hunan province and the distributions of gene polymorphisms were compared between chronic hepatitis and spontaneous clearance groups. Methods The major genotypes in rs12980275, rs12979860 and rs8099917 of IL-28B were AA, CC and TT in HIV/HCV co-infectors, which accounted for 84.1% of each. The three single nucleotide polymorphisms were highly linkage disequilibrium(r2>0.94)and the differences of genotype distribution were statistically significant between chronic hepatitis and the spontaneous clearance groups(P<0.05). Infectors which carrying the major genotypes were more susceptible to spontaneous clearance of HCV. Differences of the genotype distributions in rs760370 of ENT1 were not statistically significant between the two groups. Conclusion Genotypes AA, CC and TT of IL-28B were related to spontaneous clearance of HCV in HIV/HCV co-infectors. |
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