文章摘要
张爽,李莲,黄育北,陈可欣.成年人睡眠时间对体重增加和肥胖风险的Meta分析[J].中华流行病学杂志,2015,36(5):519-525
成年人睡眠时间对体重增加和肥胖风险的Meta分析
Meta-analysis of prospective cohort studies about sleep duration and risk of weight gain and obesity in adults
投稿时间:2015-01-04  
DOI:10.3760/cma.j.issn.0254-6450.2015.05.023
中文关键词: 肥胖;睡眠时间;体重增加;前瞻性队列研究;Meta分析
英文关键词: Obesity;Sleep duration;Weight gain;Prospective cohort study;Meta-analysis
基金项目:国家自然科学基金(81320108022, 81470153, 81473039); 天津市科学技术委员会基金(09ZCZDSF04700); 中国博士后科学基金资助项目(2012M510757)
作者单位E-mail
张爽 300060 天津, 天津医科大学肿瘤医院肿瘤分子流行病与生物统计研究室 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室  
李莲 300060 天津, 天津医科大学肿瘤医院肿瘤分子流行病与生物统计研究室 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室  
黄育北 300060 天津, 天津医科大学肿瘤医院肿瘤分子流行病与生物统计研究室 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室  
陈可欣 300060 天津, 天津医科大学肿瘤医院肿瘤分子流行病与生物统计研究室 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室 chenkexin@tijmu.edu.cn 
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中文摘要:
      目的 通过对前瞻性队列研究进行Meta分析, 探讨成年人睡眠时间和体重增加以及肥胖发生风险的关联。方法 在3个英文数据库PubMed、Embase和Cochrane Library以及3个中文数据库万方、维普、CNKI系统检索了截至2014年10月前发表的前瞻性研究, 英文检索词为sleep和body mass index或BMI或obese或obesity或weight, 中文检索词为睡眠和体重或肥胖或BMI。采用固定效应模型或者随机效应模型估计总体相对危险度(RR)和95%置信区间(CI)。结果 共有16篇文献符合纳入标准, 样本总量为285 452。相对于对照组, 睡眠过短或过多均与体重增加5 kg以上的风险有关, RR值分别为1.26(95%CI:1.12~1.42)和1.12(95%CI:1.04~1.20)。此外, 睡眠过短能显著增加肥胖的发生风险(RR=1.35, 95%CI:1.22~1.50, P<0.001), 而睡眠过久与肥胖的关联不显著。在亚组分析中, 该关联在高质量研究、以<6 h和≥8 h为界值的亚组中更强。结论 睡眠过短或过多均能显著导致体重增加, 同时睡眠过短显著增加肥胖的风险, 保持正常睡眠时间有助于防控肥胖的流行。
英文摘要:
      Objective This meta-analysis was conducted to quantitatively estimate the associations between sleep duration and weight gain or obesity in adults according to the literature retrieval results of related prospective cohort studies published before October 2014. Methods The literature retrieval was conducted by using PubMed, Embase, Cochrane Library and Chinese databases, including CNKI, VIP and Wan Fang. The pooled relative risk(RR) and 95% confidence intervals(CI) were estimated, and the tests of the publication bias and the heterogeneity were also performed. Results Sixteen literatures met the inclusion criteria were selected for analysis. In 285 452 adults surveyed in these studies, both short sleep duration and long sleep duration significantly increased the risk of weight gain (RR=1.26, 95%CI:1.12-1.42;RR=1.12, 95%CI:1.04-1.20), and short sleep duration also increased the risk of obesity (RR=1.35, 95%CI:1.22-1.50, P<0.001), but long sleep duration was not associated with obesity. In subgroup analysis, the associations were stronger in the studies with higher quality and using <6 h and ≥8 h as the criteria to identify short and long sleep durations. Conclusion The meta-analysis indicated that both short and long sleep durations were associated with weight gain, and short sleep duration could also increase the risk of obesity. Therefore, public health efforts in promoting sufficient sleep may be important in the prevention of obesity.
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