文章摘要
管文辉,朱银霞,魏庆,吴小刚,李莉,闫红静,杨蒙蒙,陈莉萍.南京市2008-2013年男男性行为人群早期梅毒及HIV感染率变化趋势分析[J].中华流行病学杂志,2015,36(6):624-628
南京市2008-2013年男男性行为人群早期梅毒及HIV感染率变化趋势分析
Trends on the changing prevalence in patients with early syphilis and HIV infection among men who having sex with men in Nanjing,from 2008 to 2013
收稿日期:2014-11-25  出版日期:2015-06-09
DOI:10.3760/cma.j.issn.0254-6450.2015.06.019
中文关键词: 男男性行为者;早期梅毒;艾滋病病毒;合并感染
英文关键词: Men who have sex with men;Early syphilis;HIV;Co-infection
基金项目:
作者单位E-mail
管文辉 210009 南京, 江苏省疾病预防控制中心 cdcgwh@126.com 
朱银霞 210009 南京, 江苏省疾病预防控制中心  
魏庆 210009 南京, 江苏省疾病预防控制中心  
吴小刚 210009 南京, 江苏省疾病预防控制中心  
李莉 210009 南京, 江苏省疾病预防控制中心  
闫红静 210009 南京, 江苏省疾病预防控制中心  
杨蒙蒙 南京医科大学公共卫生学院  
陈莉萍 210009 南京, 江苏省疾病预防控制中心  
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中文摘要:
      目的 了解南京市男男性行为人群早期梅毒、HIV感染流行水平及变化趋势,为估计疫情进展,调整、制订控制策略和干预措施提供依据.方法 对2008-2013年自愿接受艾滋病、梅毒咨询检测的男男性行为者进行梅毒和HIV感染的血清学监测,对梅毒血清学试验阳性者进行性病诊疗转介,以明确其临床诊断和分期.分析被调查人群人口学特征及早期梅毒、HIV感染和合并HIV感染的早期梅毒流行状况及其变化趋势.结果 2008-2013年各年度分别监测1 004、1 218、1 236、748、1 019和1 420名男男性行为者.各年度早期梅毒的感染率分别为2.19%、2.71%、2.43%、1.74%、3.04%和2.32%,趋势检验P> 0.05;HIV感染率分别为1.29%、2.63%、5.42%、8.82%、11.97%和10.42%,趋势检验P< 0.01;合并HIV感染的早期梅毒感染率从2008年的0.20%上升至2013年的1.06%,趋势检验P< 0.01;合并HIV感染的早期梅毒占早期梅毒的比例从2008年的9.09%上升至2013年的45.45%,趋势检验P< 0.01.结论 南京市男男性行为人群早期梅毒的流行趋于平稳,HIV感染状况上升趋势明显,合并HIV感染的早期梅毒的流行呈上升趋势,其占早期梅毒的比例也呈逐年增长的态势.在男男性行为人群中需要采取持续有效的干预措施以应对梅毒及HIV感染的流行.
英文摘要:
      Objective To observe the trends on prevalence of early syphilis and HIV infection among men who had sex with men in the last six years from a HIV/AIDS counseling and testing clinic in Nanjing,and to develop relative strategies. Methods Men who have sex with men involved in AIDS/HIV and syphilis voluntary counseling and testing services were recruited and investigated from 2008 to 2013 in this clinic. Clients whose syphilis serologic test showed positive were determined the diagnosis by physician within the referral network from sexually transmitted diseases clinics. Demographic information on early syphilis,HIV infection or co-infection with HIV and early syphilis was described while related epidemic trend analysis was performed. Results The annual numbers of men having sex with men under survey were 1 004 in 2008,1 218 in 2009,1 236 in 2010,748 in 2011,1 019 in 2012 and 1 420 in 2013. The prevalence rates of early syphilis appeared to be:2.19% in 2008,2.71% in 2009,2.43% in 2010,1.74% in 2011,3.04% in 2012 and 2.32% in 2013,with the trend as:P> 0.05. The prevalence rates of HIV infection were 1.29% in 2008,2.63% in 2009,5.42% in 2010,8.82% in 2011,11.97% in 2012 and 10.42% in 2013,with trend as:P< 0.01. The prevalence rates of early syphilis with HIV infection increased from 0.20% in 2008 to 1.06% in 2013 (trend:P< 0.01). The proportion of HIV co-infection among men having sex with men with early syphilis infection,increased from 9.09% in 2008 to 45.45% in 2013,with trend:P< 0.01. Conclusion Early syphilis infection among men who having sex with men showed a stable trend but the number of HIV and co-infections with early syphilis and HIV increased rapidly in the last six years in Nanjing. Continued intervention strategies should target on men who have sex with men to slow down the epidemic of syphilis and HIV infection.
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