文章摘要
刘金花,孙焕芹,赵艳,孙焕焕,乔桂芳,徐杰,刘宁,覃岭,李昂,江娜,张永宏.HIV对HIV/HCV共感染患者丙型肝炎病程进展的影响[J].中华流行病学杂志,2015,36(7):738-742
HIV对HIV/HCV共感染患者丙型肝炎病程进展的影响
Influence of HIV infection on hepatitis C progress in patients co-infected with HIV/HCV
投稿时间:2014-12-02  
DOI:10.3760/cma.j.issn.0254-6450.2015.07.016
中文关键词: 艾滋病病毒;丙型肝炎病毒;共感染;肝内调节性T细胞
英文关键词: HIV;Hepatitis C virus;Co-infection;Treg cells
基金项目:国家自然科学基金(81271842); 北京市自然科学基金(7132098); 首都卫生发展科研专项(首发2011-2018-06); 北京市科技计划项目(D131100005315005)
作者单位E-mail
刘金花 100069 北京, 首都医科大学附属北京佑安医院  
孙焕芹 100069 北京, 首都医科大学附属北京佑安医院  
赵艳 100069 北京, 首都医科大学附属北京佑安医院  
孙焕焕 100069 北京, 首都医科大学附属北京佑安医院  
乔桂芳 100069 北京, 首都医科大学附属北京佑安医院  
徐杰 100069 北京, 首都医科大学附属北京佑安医院  
刘宁 100069 北京, 首都医科大学附属北京佑安医院  
覃岭 100069 北京, 首都医科大学附属北京佑安医院  
李昂 100069 北京, 首都医科大学附属北京佑安医院  
江娜 100069 北京, 首都医科大学附属北京佑安医院  
张永宏 100069 北京, 首都医科大学附属北京佑安医院 13810108505@163.com 
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中文摘要:
      目的 探讨HIV感染对HIV/HCV共感染患者病情进展的影响及免疫机制。方法 研究对象为28例HIV/HCV共感染者及12例HCV单独感染者。外周血生化检测及超声Fibro-Scan评估肝脏功能及纤维化程度,采用PCR-荧光探针法检测外周血HCV病毒载量,运用流式细胞技术检测外周血Treg/CD4+T淋巴细胞百分率。结果 HIV/HCV共感染组ALT及碱性磷酸酶(ALP)水平分别为(76.16±81.248)U/L、(24.507 1±8.194)g/L,明显高于HCV单独感染组[(27.475 0±13.985) U/L、(16.966 7±7.189)g/L],差异具有统计学意义,P值分别为0.012、0.009。HIV/HCV共感染组患者肝脏纤维化指标E值为5.950 0~5.825 0 Kpa,与 HCV单独感染患者(5.150 0~1.050 0 Kpa)相比有升高趋势,P=0.077。HIV/HCV共感染者、HCV单独感染者HCV载量及病毒清除率分别为(6.476 8~5.343 4)lg copy/ml及32.14%、(1.699 0~2.681 5)lg copy/ml及75.00%,HIV/HCV共感染组HCV载量明显高于HCV单独感染组,HCV清除率低于HCV单独感染组,P值分别为0.012及0.032。HIV/HCV 共感染组Treg/CD4+T淋巴细胞百分率为(7.460 0%~2.287 5%),高于HCV单独感染组(5.965 0%~2.105 0%),差异有统计学意义(P=0.032)。并且Treg/CD4+T淋巴细胞百分率与HCV载量具有明显相关性(ρ=0.350,P=0.027),而HCV载量与肝脏纤维化程度E值存在相关性(ρ=0.487,P=0.001)。结论 HIV/HCV共感染加速丙型肝炎病情进展,而Treg细胞与丙型肝炎病情进展相关。
英文摘要:
      Objective To understand the influence of HIV infection on hepatitis C progress in patients co-infected with HIV and hepatitis C virus (HCV) and related immune mechanism. Methods Twenty eight patients co-infected with HIV/HCV and 12 patients with simplex HCV infection were enrolled. The liver function and hepatic fibrosis progress were evaluated by detecting peripheral blood and with Fibro-Scan. The viral load of HCV was detected by using real time quantitative PCR. And the percentage of Treg/CD4+T lymphocyte cell was tested by using flow cytometry. Results The levels of ALT and ALP in HIV/HCV co-infection group were (76.16±81.248)U/L, (24.507 1±8.194) g/L respectively, higher than those of simplex HCV infection group [(27.475 0±13.985)U/L, (16.966 7±7.189)g/L], the differences were statistical significant. P value was 0.012 and 0.009 respectively. The liver fibrosis index in HIV/HCV co-infection group was 5.950 0-5.825 0 Kpa, higher than that in simplex HIV infection group (5.150 0-1.050 0 Kpa), and the difference was nearly statistical significant (P=0.077). The HCV viral load in HIV/HCV co-infection group was (6.476 8-5.343 4)lg copy/ml, higher than that in simplex HCV infection group [(1.699 0- 2.681 5)lg copy/ml], and the rate of HCV clearance in HIV/HCV co-infection group was 32.14%, lower than that in simplex HCV infection group (75.00%). P value was 0.012 and 0.032 respectively. The percentage of Treg/CD4+T lymphocyte cell in HIV/HCV co-infection group was (7.460 0%- 2.287 5%), higher than that in simplex HCV infection group (5.965 0%-2.105 0%), and the difference was significant (P=0.032). The percentage of Treg/CD4+T lymphocyte cell was significantly related with HCV viral load (ρ=0.350, P=0.027), and HCV viral load was significantly related with the liver fibrosis index(ρ=0.487, P=0.001). Conclusion HIV infection could accelerate the progress of hepatitis C, and Treg cells were involved in this progress.
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