| 刘金花,孙焕芹,赵艳,孙焕焕,乔桂芳,徐杰,刘宁,覃岭,李昂,江娜,张永宏.HIV对HIV/HCV共感染患者丙型肝炎病程进展的影响[J].中华流行病学杂志,2015,36(7):738-742 |
| HIV对HIV/HCV共感染患者丙型肝炎病程进展的影响 |
| Influence of HIV infection on hepatitis C progress in patients co-infected with HIV/HCV |
| 收稿日期:2014-12-02 出版日期:2015-07-08 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.07.016 |
| 中文关键词: 艾滋病病毒 丙型肝炎病毒 共感染 肝内调节性T细胞 |
| 英文关键词: HIV Hepatitis C virus Co-infection Treg cells |
| 基金项目:国家自然科学基金(81271842); 北京市自然科学基金(7132098); 首都卫生发展科研专项(首发2011-2018-06); 北京市科技计划项目(D131100005315005) |
| 作者 | 单位 | E-mail | | 刘金花 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 孙焕芹 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 赵艳 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 孙焕焕 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 乔桂芳 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 徐杰 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 刘宁 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 覃岭 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 李昂 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 江娜 | 100069 北京, 首都医科大学附属北京佑安医院 | | | 张永宏 | 100069 北京, 首都医科大学附属北京佑安医院 | 13810108505@163.com |
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| 中文摘要: |
| 目的 探讨HIV感染对HIV/HCV共感染患者病情进展的影响及免疫机制。方法 研究对象为28例HIV/HCV共感染者及12例HCV单独感染者。外周血生化检测及超声Fibro-Scan评估肝脏功能及纤维化程度,采用PCR-荧光探针法检测外周血HCV病毒载量,运用流式细胞技术检测外周血Treg/CD4+T淋巴细胞百分率。结果 HIV/HCV共感染组ALT及碱性磷酸酶(ALP)水平分别为(76.16±81.248)U/L、(24.507 1±8.194)g/L,明显高于HCV单独感染组［(27.475 0±13.985) U/L、(16.966 7±7.189)g/L］,差异具有统计学意义,P值分别为0.012、0.009。HIV/HCV共感染组患者肝脏纤维化指标E值为5.950 0~5.825 0 Kpa,与 HCV单独感染患者(5.150 0~1.050 0 Kpa)相比有升高趋势,P=0.077。HIV/HCV共感染者、HCV单独感染者HCV载量及病毒清除率分别为(6.476 8~5.343 4)lg copy/ml及32.14%、(1.699 0~2.681 5)lg copy/ml及75.00%,HIV/HCV共感染组HCV载量明显高于HCV单独感染组,HCV清除率低于HCV单独感染组,P值分别为0.012及0.032。HIV/HCV 共感染组Treg/CD4+T淋巴细胞百分率为(7.460 0%~2.287 5%),高于HCV单独感染组(5.965 0%~2.105 0%),差异有统计学意义(P=0.032)。并且Treg/CD4+T淋巴细胞百分率与HCV载量具有明显相关性(ρ=0.350,P=0.027),而HCV载量与肝脏纤维化程度E值存在相关性(ρ=0.487,P=0.001)。结论 HIV/HCV共感染加速丙型肝炎病情进展,而Treg细胞与丙型肝炎病情进展相关。 |
| 英文摘要: |
| Objective To understand the influence of HIV infection on hepatitis C progress in patients co-infected with HIV and hepatitis C virus (HCV) and related immune mechanism. Methods Twenty eight patients co-infected with HIV/HCV and 12 patients with simplex HCV infection were enrolled. The liver function and hepatic fibrosis progress were evaluated by detecting peripheral blood and with Fibro-Scan. The viral load of HCV was detected by using real time quantitative PCR. And the percentage of Treg/CD4+T lymphocyte cell was tested by using flow cytometry. Results The levels of ALT and ALP in HIV/HCV co-infection group were (76.16±81.248)U/L, (24.507 1±8.194) g/L respectively, higher than those of simplex HCV infection group ［(27.475 0±13.985)U/L, (16.966 7±7.189)g/L］, the differences were statistical significant. P value was 0.012 and 0.009 respectively. The liver fibrosis index in HIV/HCV co-infection group was 5.950 0-5.825 0 Kpa, higher than that in simplex HIV infection group (5.150 0-1.050 0 Kpa), and the difference was nearly statistical significant (P=0.077). The HCV viral load in HIV/HCV co-infection group was (6.476 8-5.343 4)lg copy/ml, higher than that in simplex HCV infection group ［(1.699 0- 2.681 5)lg copy/ml］, and the rate of HCV clearance in HIV/HCV co-infection group was 32.14%, lower than that in simplex HCV infection group (75.00%). P value was 0.012 and 0.032 respectively. The percentage of Treg/CD4+T lymphocyte cell in HIV/HCV co-infection group was (7.460 0%- 2.287 5%), higher than that in simplex HCV infection group (5.965 0%-2.105 0%), and the difference was significant (P=0.032). The percentage of Treg/CD4+T lymphocyte cell was significantly related with HCV viral load (ρ=0.350, P=0.027), and HCV viral load was significantly related with the liver fibrosis index(ρ=0.487, P=0.001). Conclusion HIV infection could accelerate the progress of hepatitis C, and Treg cells were involved in this progress. |
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