文章摘要
周琳,吴琼海,沈伟伟,高眉扬,丁盈盈,林海江,何纳.浙江省台州市新报告成年HIV感染者中HCV合并感染研究[J].中华流行病学杂志,2015,36(8):862-866
浙江省台州市新报告成年HIV感染者中HCV合并感染研究
Co-infection of hepatitis C virus among newly diagnosed HIV-infected adults in Taizhou prefecture of Zhejiang province, China
收稿日期:2015-01-27  出版日期:2015-08-11
DOI:10.3760/cma.j.issn.0254-6450.2015.08.020
中文关键词: 艾滋病病毒;丙型肝炎病毒;合并感染;病毒载量
英文关键词: HIV;Hepatitis C virus;Coinfection;Viral load
基金项目:国家自然科学基金(81373062)
作者单位E-mail
周琳 200032 上海, 复旦大学公共卫生学院 公共卫生安全教育部重点实验室  
吴琼海 浙江省台州市疾病预防控制中心  
沈伟伟 浙江省台州市疾病预防控制中心  
高眉扬 200032 上海, 复旦大学公共卫生学院 公共卫生安全教育部重点实验室  
丁盈盈 200032 上海, 复旦大学公共卫生学院 公共卫生安全教育部重点实验室  
林海江 200032 上海, 复旦大学公共卫生学院 公共卫生安全教育部重点实验室
浙江省台州市疾病预防控制中心 
linhaijiang@hotmail.com 
何纳 200032 上海, 复旦大学公共卫生学院 公共卫生安全教育部重点实验室 nhe@shmu.edu.cn 
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中文摘要:
      目的 了解浙江省台州市2009-2012年新报告成年HIV感染者中合并感染HCV的情况, 分析HIV/HCV合并感染者中血浆HCV病毒载量水平。 方法 对2009-2012年浙江省台州市新报告的572例成年HIV感染者检测HCV抗体, 并对HCV抗体阳性的标本进行HCV RNA定量检测。 结果 共有42例HCV抗体检测阳性, HIV感染者中HCV合并感染率为7.3%(95%CI: 5.2%~9.5%)。46~86岁HIV感染者的HCV合并感染率显著低于18~45岁年龄组(OR=0.12, 95%CI: 0.02~0.58);高中及以上文化程度的HIV感染者HCV合并感染率显著低于小学及以下文化程度者(OR=0.13, 95%CI: 0.02~0.78);经血传播HIV感染者HCV合并感染率显著高于异性传播HIV感染者(OR=49.46, 95%CI: 13.71~178.48);同性传播HIV感染者HCV合并感染率则低于异性传播HIV感染者(OR=0.11, 95%CI: 0.01~0.86)。42例HIV/HCV合并感染者中33例(78.6%)血浆HCV病毒载量在检测限以上, HCV复制相对活跃, 其中HBsAg阳性者血浆HCV RNA检出率(100%)显著高于HBsAg阴性者(75.7%)(P=0.002)。9例(21.4%)血浆HCV病毒载量则低于检测下限(5.0×102 IU/ml), 处于相对抑制状态。单因素logistic回归分析未发现HIV/HCV合并感染者HCV相对抑制率与其社会人口学特征、HIV传播途径、CD4+T淋巴细胞计数等有关联。 结论 浙江省台州市HIV感染者中HCV感染率较高, 多数HIV/HCV合并感染者血浆HCV病毒载量也较高, 其对病情进展影响有待持续观察。
英文摘要:
      Objective To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province, China. Methods Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG). Plasma HCV RNA was quantified if positive for HCV IgG. Results Forty-two (7.3%) out of the 572 HIV-infected adults were tested positive for HCV IgG. HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR=49.46, 95%CI: 13.71-178.48). Otherwise, HCV infection was less likely to occur among participants who were under 46-86 years of age (OR=0.12, 95%CI: 0.02-0.58), those with mode of homosexual transmission of HIV (OR=0.11, 95%CI: 0.01-0.86), with education of high school or above (OR=0.13, 95%CI: 0.02-0.78). Thirty-three (78.6%) of the total 42 HIV-HCV patients with coinfection had detectable plasma HCV RNA, whereas 9(21.4%) had undetectable plasma HCV RNA (i.e., lower than 5.0×102 IU/ml) or known as relative HCV viral suppression. No significant associations were noticed on factors as: HCV viral suppression and demographics, HIV transmission route and CD4+ T-cell counts according to univariate regression analyses. Conclusion Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area. Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA, of which the long term impact on disease progression deserves called for further research.
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