文章摘要
蔡晓楠,张丹丹,严亚琼,谈迪心,许奕华.耐多药结核病发病危险因素的Meta分析[J].中华流行病学杂志,2015,36(12):1424-1429
耐多药结核病发病危险因素的Meta分析
Meta-analysis on risk factors of multidrug resistant tuberculosis in China
收稿日期:2015-03-25  出版日期:2015-12-15
DOI:10.3760/cma.j.issn.0254-6450.2015.12.024
中文关键词: 耐多药结核病;危险因素;Meta分析
英文关键词: Multidrug resistant tuberculosis;Risk factor;Meta-analysis
基金项目:华中科技大学自主创新研究基金前沿探索(2013TS004)
作者单位E-mail
蔡晓楠 430030 武汉, 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系  
张丹丹 430030 武汉, 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系  
严亚琼 武汉市疾病预防控制中心  
谈迪心 430030 武汉, 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系  
许奕华 430030 武汉, 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系 xuyihua_6@hotmail.com 
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中文摘要:
      目的 系统评价中国居民耐多药结核病(MDR-TB)发生的主要危险因素。方法 计算机检索英文数据库PubMed及中文数据库中国知网(CNKI)、万方数据知识服务平台(Wanfang)、中国生物医学文献服务系统(SinoMed)与维普期刊资源整合服务平台(VIP) 中1990-2013年与MDR-TB发病危险因素有关的研究,同时手工检索相关资料。严格按照纳入和排除标准对所获文献进行筛选、提取资料和质量评价,之后应用Stata 11.0软件进行Meta分析。结果 最终纳入文献共25篇。Meta分析显示,汉族、结核病治疗史、肺部空洞、流动人口、结核病患者接触史、规律服药、居住在农村和家庭经济状况差与MDR-TB发病相关,各因素分析合并OR值及其95%CI值分别为3.12(1.16~8.40)、5.27(3.60~7.72)、1.39(1.03~1.87)、1.69(1.07~2.68)、4.34(1.91~9.86)、0.23(0.16~0.35)、1.86(1.59~2.18)和1.62(1.34~1.96)。结论 汉族、结核治疗史、肺部空洞、流动人口、结核接触史、居住在农村、家庭经济状况差是MDR-TB发病的危险因素,规律服药是其保护因素。
英文摘要:
      Objective To synthetically evaluate the risk factors of multidrug resistant tuberculosis (MDR-TB) in China. Methods Chinese databases(CNKI, Wanfang, SinoMed and VIP) and English database(PubMed) were used to collect studies on risk factors for MDR-TB from 1990 to 2013. Meanwhile, relevant studies were manually retrieved. According to the inclusion and exclusion criteria, studies were screened, data were extracted and quality assessed. A Meta-analysis was performed by using Stata 11.0 software. Results Twenty five studies on the risk factors of MDR-TB were synthetically and quantitatively analyzed. The results of Meta-analysis showed that factors as: being Han ethnic group, history of tuberculosis treatment,pulmonary cavity,floating population,TB case contact history,regular medication, living in rural areas,and poor economy were associated with the incidence of MDR-TB, the pooled OR values were 3.12 (95%CI:1.16-8.40), 5.27(95%CI:3.60-7.72), 1.39(95%CI:1.03-1.87), 1.69(95%CI:1.07-2.68), 4.34(95%CI: 1.91-9.86), 0.23(95%CI:0.16-0.35), 1.86(95%CI:1.59-2.18) and 1.62(95%CI:1.34-1.96), respectively. Conclusion Factors as: being Han ethnic group, history of tuberculosis treatment,pulmonary cavity, floating population, TB case contact history, living in rural areas and poor economy were considered to be at risk of MDR-TB while regular medication might be a protective factor to MDR-TB.
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