文章摘要
鲍萍萍,吴春晓,顾凯,龚杨明,彭鹏,黄哲宙,张敏璐,郑莹,仲伟鉴.上海市儿童恶性肿瘤发病情况和时间趋势分析[J].中华流行病学杂志,2016,37(1):106-110
上海市儿童恶性肿瘤发病情况和时间趋势分析
Incidence trend of malignant tumors in children in Shanghai
收稿日期:2015-05-25  出版日期:2016-01-12
DOI:10.3760/cma.j.issn.0254-6450.2016.01.023
中文关键词: 儿童恶性肿瘤  发病率  发病趋势  流行病学
英文关键词: Childhood cancer  Incidence  Incidence trend  Epidemiology
基金项目:上海市卫生局公共卫生优秀青年人才计划(08GWQ032)
作者单位E-mail
鲍萍萍 200336 上海市疾病预防控制中心肿瘤防治科  
吴春晓 200336 上海市疾病预防控制中心肿瘤防治科  
顾凯 200336 上海市疾病预防控制中心肿瘤防治科  
龚杨明 200336 上海市疾病预防控制中心肿瘤防治科  
彭鹏 200336 上海市疾病预防控制中心肿瘤防治科  
黄哲宙 200336 上海市疾病预防控制中心肿瘤防治科  
张敏璐 200336 上海市疾病预防控制中心肿瘤防治科  
郑莹 200336 上海市疾病预防控制中心肿瘤防治科  
仲伟鉴 200336 上海市疾病预防控制中心肿瘤防治科 zhongweijian@scdc.sh.cn 
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中文摘要:
      目的 描述上海市 <15岁儿童恶性肿瘤发病情况和发病变化趋势。方法 利用上海市恶性肿瘤病例报告系统收集的儿童恶性肿瘤发病资料,采用儿童肿瘤国际分类(ICCC-3)进行归类,分析2009-2011年上海市儿童恶性肿瘤的发病情况及其性别、年龄别分布特征,并应用Joinpoint软件计算年度变化百分比(APC),对2002-2013年上海市儿童恶性肿瘤发病率时间趋势进行分析。结果 2009-2011年上海市共诊断儿童恶性肿瘤病例460例,占所有部位肿瘤的0.3%,粗发病率为129.0/100万,标化发病率(ASR)为129.6/100万。男童恶性肿瘤发病率高于女童,ASR分别为142.1/100万和116.4/100万,男女童发病比为1.2(95%CI:1.0~1.5)。白血病是最常见的儿童恶性肿瘤(35.9%,165/460,ASR:47.0/100万),其次为中枢神经系统(19.8%,91/460,ASR:25.6/100万)和淋巴瘤(9.8%,45/460,ASR:12.6/100万)。2002-2011年性别、年龄组(0~、5~和10~14岁)儿童恶性肿瘤发病率无明显改变,不同肿瘤[白血病、中枢神经系统(CNS)肿瘤以及淋巴瘤]发病率也无明显改变。结论 上海市男童恶性肿瘤发病率高于女童。白血病、CNS肿瘤和淋巴瘤是最常见的儿童恶性肿瘤。2002-2011年上海市儿童恶性肿瘤发病率无明显改变。
英文摘要:
      Objective To understand the incidence trend of malignant tumors in children aged <15 years in Shanghai. Methods The <15 years old children diagnosed with cancer in Shanghai between 2009 and 2011 were included in this study. The types of malignant tumors were classified according to International Classification of Childhood Cancer, Version 3 (ICCC-3). The gender and age specific incidences of malignant tumors were analyzed. Software Joinpoint was used to calculate the annual percentage of childhood cancer cases. Results A total of 460 cases of childhood cancer were diagnosed in Shanghai during 2009-2011, accounting for 0.3% of total cancer cases. The crude incidence was 129.0 per million and the age standardized rate (ASR) was 129.6 per million. The ASR was higher in boys (142.1 per million) than in girls (116.4 per million). The boy to girl ratio was 1.2(95%CI: 1.0-1.5). The incidence was highest in age group <5 years (165.1 per million). The incidences in age groups 5-9 years and 10-14 years were 101.2 per million and 113.9 per million, respectively. Leukemia was the most common cancer in children (n=165, 35.9%, ASR: 47.0 per million), followed by central nervous system tumors (n=91, 19.8%, ASR: 25.6 per million) and lymphomas (n=45, 9.8%, ASR: 12.6 per million). The age and gender specific incidence of malignant tumors and the type specific incidence of malignant tumors in children in Shanghai had no significant changes during the study period. Conclusions The incidence of malignant tumors was higher in boys than in girls in Shanghai. Leukemia, central nervous system tumors and lymphomas were the three most common cancers in children. The overall incidence of malignant tumors in children in Shanghai had no significant changes during 2002-2011.
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