| 朱怡青,陈保立,毕振旺,寇增强,胡彬,房明,毕振强.我国医院中社区获得性耐甲氧西林金黄色葡萄球菌流行情况的Meta分析[J].中华流行病学杂志,2016,37(2):273-280 |
| 我国医院中社区获得性耐甲氧西林金黄色葡萄球菌流行情况的Meta分析 |
| Meta-analysis on epidemiology of iatrogenic-borne methicillin-resistant Staphylococcus aureus |
| 收稿日期:2015-05-07 出版日期:2016-02-18 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.02.025 |
| 中文关键词: 耐甲氧西林金黄色葡萄球菌 社区获得性感染 医院感染 杀白细胞毒素 耐药性 |
| 英文关键词: Methicillin-resistant Staphylococcus aureus Community acquired infection Nosocomial infection Panton-valentine leucocidin Drug resistance |
| 基金项目:国家科技重大专项(2012ZX10004210-003);山东省优秀中青年科学家科研奖励基金项目(BS2014SW020) |
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| 中文摘要: |
| 目的 通过Meta分析了解我国医院发现的社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)的分子生物学特征和流行病学现状。方法 系统检索2015年12月3日前收录于中国知网(CNKI)、万方数据库、PubMed和Web of Science核心合集的期刊或学位论文,遵照PRISMA规范进行Meta分析,利用Stata 13.0软件对医院发现的CA-MRSA检出率、杀白细胞素基因(PVL)基因携带率等数据进行合并,对医院和社区的CA-MRSA检出率进行比较。结果 医院患者中检出的CA-MRSA占金黄色葡萄球菌的12%(95% CI:8%~16%);占MRSA的18%(95% CI:12%~24%);CA-MRSA中PVL携带率约为42.1%(95% CI:20.4%~63.7%),高于一般的MRSA(t=-2.99,P=0.011)。结论 我国医院中CA-MRSA检出率较低,但PVL基因携带率高。需采取有效监测和预防措施,以达到控制CA-MRSA在人群中传播的目的。 |
| 英文摘要: |
| Objective To study the molecular-biologic characteristics and epidemiological status of iatrogenic related Community-acquired methicillin-resistant Staphylococcus(S.) aureus(CA-MRSA) in China through Meta-analysis.Methods Data through systematic searching for peer-reviewed articles published before December 3rd, 2015 from 4 main electronic databases including China National Knowledge Infrastructure(CNKI), Wanfang Data, PubMed and Web of Science Core Collection was collected, for this Meta-analysis.PRISMA guidelines were followed and the proportion of MRSA, CA-MRSA, hospital-acquired MRSA(HA-MRSA) and panton-valentine leucocidin(PVL) gene in certain populations were quantitatively analyzed by Stata 13.0 software.Results Average proportion of CA-MRSA from S.aureus was 12%(95% CI:8%-16%).CA-MRSA in MRSA was 18%(95% CI:12%-24%).42.1%(95% CI:20.4%-63.7%) of the CA-MRSA carried a PVL gene, and the number was higher than general MRSA(t=-2.99, P=0.011).Conclusion CA-MRSA was in lower proportion than HA-MRSA, both seen in general MRSA and in S.aureus, but under higher proportion of carrying the PVL gene.Transmission of CA-MRSA could be prevented within the general population through conducting effective surveillances and preventive programs. |
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