文章摘要
周龙,赵连成,李莹,郭敏,武阳丰.成年早期体重状态及至中年期体重变化与新发2型糖尿病的关系[J].中华流行病学杂志,2016,37(3):339-343
成年早期体重状态及至中年期体重变化与新发2型糖尿病的关系
Relationship between body weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus
收稿日期:2015-08-22  出版日期:2016-03-15
DOI:10.3760/cma.j.issn.0254-6450.2016.03.009
中文关键词: 体重;肥胖;糖尿病,2型
英文关键词: Body weight;Obesity;Type 2 diabetes mellitus
基金项目:国家"九五"科技攻关计划(96-906-02-01)
作者单位E-mail
周龙 100037 北京, 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院社区防治部  
赵连成 100037 北京, 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院社区防治部 zhaolch@163.com 
李莹 100037 北京, 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院社区防治部  
郭敏 100037 北京, 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院社区防治部  
武阳丰 100191 北京大学公共卫生学院流行病与卫生统计学系  
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中文摘要:
      目的 探讨成年早期体重状态及至中年期体重变化与2型糖尿病间的关系。方法 利用中国心血管流行病学多中心协作研究的14组35~59岁(男女各半)人群样本心血管病危险因素调查资料,采用多因素logistic回归分别探讨25岁时体重状态和随后其变化与新发糖尿病的关系。结果 共12 674人纳入分析,其25岁时低体重组(BMI<18.5 kg/m2)、正常体重组(BMI 18.5~23.9 kg/m2)、超重组(BMI 24.0~27.9 kg/m2)和肥胖组(BMI≥28.0 kg/m2)中年期糖尿病发病率分别为2.4%(30/1 263)、2.8%(266/9 562)、4.0%(70/1 739)和6.4%(7/110),呈明显上升趋势(趋势检验P<0.01)。25岁至中年时期体重变化<-7.5 kg组、-7.5~-2.6 kg组、-2.5~2.5 kg组、2.6~7.5 kg组、7.6~12.5 kg组和>12.5 kg组糖尿病发病率分别为2.5%(18/712)、1.3%(21/1 629)、2.1%(48/2 330)、2.3%(59/2 585)、3.7%(94/2 518)和4.6%(133/2 900),也呈明显上升趋势(趋势检验P<0.01)。多因素logistic回归分析显示,25岁时超重/肥胖以及随后的体重增加均与中年时期新发糖尿病正相关(趋势检验P<0.01)。结论 成年早期超重/肥胖以及随后的体重增加均与中年期新发糖尿病独立相关。
英文摘要:
      Objective To explore the relationship between weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus (T2DM). Methods The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used. Approximately 1 000 men and women in each sample were surveyed for cardiovascular disease risk factors, including body weight at age 25 years. The body mass index (BMI) at the age 25 years was calculated. The association between body weight in early adulthood and body weight change at middle age and T2DM was examined by using logistic regression model. Results The incidence of T2DM in low weight group (BMI<18.5 kg/m2), normal weight group (BMI: 18.5-23.9 kg/m2), overweight group (BMI: 24.0-27.9 kg/m2) and obese group (BMI:≥28.0 kg/m2) at 25 years old were 2.4%(30/1 263), 2.8%(266/9 562), 4.0%(70/1 739) and 6.4%(7/110), respectively (P value for trend<0.01). The incidence of T2DM for adults with weight change <-7.5 kg, -7.5- -2.6 kg, -2.5-2.5 kg, 2.6-7.5 kg, 7.6-12.5 kg and >12.5 kg at middle age were 2.5% (18/712), 1.3%(21/1 629), 2.1%(48/2 330), 2.3%(59/2 585), 3.7%(94/2 518), and 4.6%(133/2 900) respectively. (P value for trend <0.01), Multivariate logistic regression analysis showed that overweight and obesity at age 25 years and subsequent weight gain were positively correlated with T2DM after adjusted other risk factors (all P values for trend <0.01). Conclusion Overweight and obesity in early adulthood and weight gain at middle age were both independently associated with the increased risk of T2DM in middle-aged men and women.
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