文章摘要
李佳媚,屈鹏飞,党少农,李姗姗,柏如海,秦博文,颜虹.陕西省育龄妇女围孕期增补叶酸对新生儿出生体重的影响[J].中华流行病学杂志,2016,37(7):1017-1020
陕西省育龄妇女围孕期增补叶酸对新生儿出生体重的影响
Effect of folic acid supplementation in childbearing aged women during pregnancy on neonate birth weight in Shaanxi province
收稿日期:2016-01-06  出版日期:2016-07-15
DOI:10.3760/cma.j.issn.0254-6450.2016.07.022
中文关键词: 出生体重  叶酸  分位数回归
英文关键词: Birth weight  Folic acid  Quantile regression
基金项目:国家自然科学基金(81230016)
作者单位E-mail
李佳媚 710061 西安交通大学医学部流行病与卫生统计学教研室  
屈鹏飞 710061 西安交通大学医学部流行病与卫生统计学教研室  
党少农 710061 西安交通大学医学部流行病与卫生统计学教研室  
李姗姗 710061 西安交通大学医学部流行病与卫生统计学教研室  
柏如海 710061 西安交通大学医学部流行病与卫生统计学教研室  
秦博文 710061 西安交通大学医学部流行病与卫生统计学教研室  
颜虹 710061 西安交通大学医学部流行病与卫生统计学教研室 yanhonge@mail.xjtu.edu.cn 
摘要点击次数: 2845
全文下载次数: 1473
中文摘要:
      目的 探讨陕西省育龄妇女围孕期增补叶酸对新生儿出生体重的影响。方法 采用分层多阶段随机抽样方法,以问卷调查方式收集2010-2013年陕西省怀孕且结局明确的育龄妇女及其子女的相关信息。将新生儿出生体重和母亲围孕期是否增补叶酸分别以因变量和自变量纳入多重线性回归及分位数回归模型,并控制相关混杂因素。结果 多重线性回归结果显示,围孕期增补叶酸者子女的出生体重高于未增补者,平均提高29.56 g(B=29.56,t=4.69,P<0.01)。分位数回归结果显示,当新生儿出生体重处于q=0~0.55、q=0.65、q=0.75~0.80百分位点时,增补过叶酸的母亲所生育子女的出生体重高于未增补者,差异有统计学意义,且体重提高的幅度不一致,随着出生体重百分位点的增高,增补过叶酸的母亲所生育子女的出生体重与未增补者相比提高幅度逐渐减小。结论 围孕期增补叶酸可以提高新生儿出生体重,对体重较轻的新生儿影响更大,体重较重的新生儿影响较小甚至无影响。
英文摘要:
      Objective To investigate the effect of folic acid supplementation in childbearing aged women during pregnancy on the birth weight of newborns in Shaanxi province. Methods A questionnaire survey was conducted among the childbearing aged women selected through multistage stratified random sampling in Shaanxi during 2010-2013, all of these childbearing aged women were in pregnancy or had definite pregnancy outcomes. The birth weight of newborns and folic acid supplementation during pregnancy were used as the dependent variables and independent variables respectively in multiple linear regression model and quantile regression model and confounding factors were controlled. Results Multiple linear regression analysis showed that the birth weight of newborns whose mothers had folic acid supplementation during pregnancy were significantly higher than those whose mothers had no folic acid supplementation during pregnancy, an average increase of 29.56 g (B=29.56, t=4.69 and P<0.01). Quantile regression analysis showed from very low to higher percentiles (q=0-0.55, q=0.65, q=0.75-0.80), the birth weights of newborns whose mothers supplemented folic acid were higher than those whose mother did not supplement folic acid, the difference was significant, but the increase varied. As the increase of the percentiles of birth weight, the body weight increase declined gradually in those whose mothers had folic acid supplementation compared with those whose mothers had no folic acid supplementation. Conclusion Folic acid supplementation during pregnancy can increase the birth weight of newborns, the influence was greater in newborns with lower body weight than in newborns with higher body weight.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭