文章摘要
向韧,戴文杰,熊元,吴鑫,杨艳芳,王玲,戴志辉,李娇,刘爱忠.有向无环图在因果推断控制混杂因素中的应用[J].中华流行病学杂志,2016,37(7):1035-1038
有向无环图在因果推断控制混杂因素中的应用
Application of directed acyclic graphs in control of confounding
投稿时间:2015-11-18  
DOI:10.3760/cma.j.issn.0254-6450.2016.07.025
中文关键词: 病因学研究;有向无环图;混杂因素;因果关系
英文关键词: Etiology study;Directed acyclic graph;Confounder;Causality
基金项目:
作者单位E-mail
向韧 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
戴文杰 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
熊元 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
吴鑫 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
杨艳芳 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
王玲 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
戴志辉 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
李娇 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系  
刘爱忠 410008 长沙, 中南大学公共卫生学院流行病与卫生统计学系 lazroy@live.cn 
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中文摘要:
      观察性研究是流行病学病因研究中最常用的方法之一,但在因果推断时混杂因素往往会歪曲暴露与结局的真实因果关联。为了消除混杂,选择变量调整是关键所在。有向无环图能够将复杂的因果关系可视化,提供识别混杂的直观方法,将识别混杂转变成识别最小充分调整集。一方面有向无环图可以选择调整更少的变量,增加分析的统计效率;另一方面有向无环图识别的最小充分调整集可以避开未被测量或有缺失值的变量。总之,有向无环图有助于充分揭示真实的因果关系。
英文摘要:
      Observational study is a method most commonly used in the etiology study of epidemiology, but confounders, always distort the true causality between exposure and outcome when local inferencing. In order to eliminate these confounding, the determining of variables which need to be adjusted become a key issue. Directed acyclic graph (DAG) could visualize complex causality, provide a simple and intuitive way to identify the confounding, and convert it into the finding of the minimal sufficient adjustment for the control of confounding. On the one hand, directed acyclic graph can choose less variables, which increase statistical efficiency of the analysis. On the other hand, it could help avoiding variables that is not measured or with missing values. In a word, the directed acyclic graph could facilitate the reveal of the real causality effectively.
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