文章摘要
高莹,高文静,曹卫华.儿童青少年肥胖与DNA甲基化关联研究进展[J].中华流行病学杂志,2016,37(8):1169-1174
儿童青少年肥胖与DNA甲基化关联研究进展
Current status and progress in studies on the association between obesity and DNA methylation among children and adolescents
收稿日期:2016-01-21  出版日期:2016-08-10
DOI:10.3760/cma.j.issn.0254-6450.2016.08.023
中文关键词: 肥胖;DNA甲基化;表观遗传学;儿童青少年
英文关键词: Obesity;DNA methylation;Epigenetics;Children and adolescents
基金项目:国家自然科学基金(81473041)
作者单位E-mail
高莹 100191 北京大学公共卫生学院流行病与卫生统计学系  
高文静 100191 北京大学公共卫生学院流行病与卫生统计学系  
曹卫华 100191 北京大学公共卫生学院流行病与卫生统计学系 caoweihua60@163.com 
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中文摘要:
      DNA甲基化是目前研究最常见的表观遗传现象,有助于从生物学机制上解释遗传因素、环境因素及基因-环境因素交互作用对于肥胖的影响。生命早期DNA甲基化研究对于预防和控制肥胖具有重要作用,国内此方面研究尚缺乏。本研究通过回顾儿童青少年肥胖与DNA甲基化关联研究现状,介绍DNA甲基化研究的主要原理、基本特点及其与肥胖关联研究的主要结果,为今后相关研究提供依据。
英文摘要:
      DNA methylation is one of the most commonly recognized epigenetic phenomenon, which explains how genes, environmental factors and gene-environment interaction would cause obesity, integretedly. Studies on early life obesity-related epigenetic reveal important effects that related to the programs on prevention and control of obesity. However, only few similar studies have been conducted in China. This paper summarizes the basic principles, characteristics of DNA methylation and the major results of children and adolescents obesity-related research areas, in order to provide evidence for further studies.
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