文章摘要
王浩,胡如英,钟节鸣,钱一建,王春梅,谢开婿,陈玲琍,卞铮,郭彧,俞敏,陈铮鸣,李立明.成年女性初潮年龄与糖尿病患病关系及交互作用的研究[J].中华流行病学杂志,2016,37(10):1361-1365
成年女性初潮年龄与糖尿病患病关系及交互作用的研究
Association and interaction between age at menarche and risk of diabetes in adult women
收稿日期:2016-07-08  出版日期:2016-10-13
DOI:10.3760/cma.j.issn.0254-6450.2016.10.009
中文关键词: 初潮年龄  糖尿病  患病率  交互作用
英文关键词: Menarche age  Diabetes  Prevalence  Interaction
基金项目:国家自然科学基金(81390541,81390544);香港Kadoorie Charitable Foundation;英国Wellcome Trust(088158/Z/09/Z)
作者单位E-mail
王浩 310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所  
胡如英 310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所  
钟节鸣 310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所  
钱一建 314500 桐乡市疾病预防控制中心慢病科  
王春梅 314500 桐乡市疾病预防控制中心慢病科  
谢开婿 314500 桐乡市疾病预防控制中心慢病科  
陈玲琍 314500 桐乡市疾病预防控制中心慢病科  
卞铮 100730 北京, 中国医学科学院  
郭彧 100730 北京, 中国医学科学院  
俞敏 310051 杭州, 浙江省疾病预防控制中心慢性非传染性疾病预防控制所 myu@cdc.zj.cn 
陈铮鸣 OX37LF 牛津, 英国牛津大学临床与流行病学研究中心  
李立明 100730 北京, 中国医学科学院
100191 北京大学公共卫生学院 
lmlee@pumc.edu.cn 
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中文摘要:
      目的 探讨成年女性初潮年龄与糖尿病患病的关系。方法 使用“中国慢性病前瞻性研究”浙江省桐乡市项目点32 364名30~79岁女性常住居民有效基线调查数据,使用多重logistic回归分析,通过调整可能的混杂因素研究初潮年龄与糖尿病患病的关系,使用回归模型中初潮年龄与不同变量的乘积项,评价二者的交互作用。结果 调查对象平均年龄为(51.42±9.63)岁,3.73%的女性初潮年龄≤12岁,24.17%的女性初潮年龄≥17岁。调查对象糖尿病患病率为5.75%。调整年龄、社会经济状况、糖尿病家族史、行为习惯、闭经、BMI和腰围等因素后,与初潮年龄≥17岁相比,初潮年龄15~16、13~14和≤12岁女性成年后糖尿病患病OR值(95% CI)分别为1.13(1.00~1.27)、1.29(1.12~1.49)和1.68(1.31~2.15)。吸烟、饮酒、体力活动、肥胖等与初潮年龄无相乘交互作用(P>0.05)。结论 初潮年龄与女性糖尿病患病存在着关联。初潮年龄越早,成年后患糖尿病风险越大。初潮年龄和吸烟等成年期暴露因素对糖尿病无相乘交互作用。
英文摘要:
      Objective To explore the associations between age at menarche and diabetes in adult women. Methods We analyzed the baseline data of 32 364 female participants who were aged 30-79 years and had been enrolled into China Kadoorie Biobank (CKB) study from Tongxiang, Zhejiang province. Multiple logistic regression analysis were used to investigate the putative associations after adjusting for potential confounders. Variables of menarche age and others were added to the logistic regression model to evaluate the multiplicative interaction, respectively. Results The mean age of female participants was (51.42±9.63) years. And 3.73% and 24.17% of them reported their menarche age, ≤12 years, ≥17 years, respectively. The prevalence of diabetes among them was 5.75%. Compared with those with menarche age ≤12 years, the OR(95%CI) of 15-16, 13-14 and ≤12 years group were 1.13(1.00-1.27), 1.29(1.12-1.49) and 1.68(1.31-2.15) after adjusting for age, socioeconomic status, family history, health behaviors, menopause status, BMI and waist circumference. No significant differences were found in multiplicative interaction on diabetes between menarche age and smoking, alcohol consumption, physical activity, obesity, etc. (P>0.05). Conclusions Menarche age is associated with higher risk of diabetes in female adults. The earlier menarche age is the higher risk of diabetes. There are no multiplicative interaction on diabetes between menarche age and other adults factors.
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