文章摘要
吴楠楠,殷玥琪,袁瑞,王蓓.我国HIV亚型与耐药性Meta分析[J].中华流行病学杂志,2016,37(11):1546-1554
我国HIV亚型与耐药性Meta分析
HIV genetic subtypes and HIV drug resistance in China: a Meta-analysis
收稿日期:2016-05-23  出版日期:2016-11-10
DOI:10.3760/cma.j.issn.0254-6450.2016.11.022
中文关键词: 耐药  艾滋病病毒  病毒亚型  Meta分析
英文关键词: Drug resistance  HIV  Virus subtype  Meta-analysis
基金项目:教育部博士点基金(20130092110048);中央高校基本科研业务费专项资金
作者单位E-mail
吴楠楠 210009 南京, 东南大学公共卫生学院  
殷玥琪 210009 南京, 东南大学公共卫生学院  
袁瑞 210009 南京, 东南大学公共卫生学院  
王蓓 210009 南京, 东南大学公共卫生学院 wangbeilxb@seu.edu.cn 
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中文摘要:
      目的 系统评价我国HIV感染者不同亚型与耐药的关系。方法 计算机检索维普中文科技期刊全文数据库(VIP)、万方数据库(Wangfang Data)、中国期刊全文数据库(CNKI)、PubMed、Web of Science等数据库中2005-2015年与HIV亚型耐药相关研究,同时手工检索相关资料。严格按照纳入标准和排除标准对所获文献进行筛选、提取资料和质量评价,然后用Stata 12.0软件进行Meta分析。结果 最终纳入文献43篇,整体耐药率为15.1%,原发耐药率为9.5%,与耐药相关的亚型主要有CRF01_AE、CRF07_BC、CRF08_BC、B/B'和C亚型,在整个人群中,各亚型合并耐药率分别为12.8%、7.4%、14.3%、25.7%、34.9%;各亚型原发耐药率分别为7.3%、5.7%、11.5%、15.5%和23.9%。亚组分析结果显示,处理和区域亚组组内差异有统计学意义(P<0.05);各亚型原发耐药率在区域上呈现华北、西南地区高于中南地区。结论 我国不同的HIV亚型地区分布较为广泛,各亚型原发性耐药率较高,呈现较大差异,需要加强对我国不同亚型耐药毒株监测,以防止耐药毒株间的重组与传播。
英文摘要:
      Objective To assess the relationship between HIV genetic subtypes and HIV resistance in China. Methods The literature retrieval was conducted by using Chinese Science-Technology Journal Database (VIP), Wanfang Data, Chinese Journal Full-text Database (CNKI), PubMed and Web of Science to select the papers on the relationship between HIV subtypes and HIV drug resistance in China during 2005-2015. Eligible papers were included according to the inclusion. Meta-analysis was performed by using software Stata 12.0. Results A total of 43 papers were selected and the pooled rate of drug resistance was 15.1% and the rate of primary drug resistance was 9.5%, the subtypes associated drug resistance were CRF01_AE, CRF07_BC, CRF08_ BC, B/B'and C. The pooled rates of drug resistance of each subtype were 12.8%, 7.4%, 14.3%, 25.7% and 34.9% and the rates of primary drug resistance of each subtype were 7.3%, 5.7%, 11.5%,15.5% and 23.9%, respectively. Subgroup analysis showed that both treated and area subgroup showed a significant difference among groups (P<0.05). The rates of primary resistance of each subtype in northern China and southwestern China were higher than that in southern China. Conclusion The distribution of HIV genotypes in China was complex and the prevalence of primary drug resistance of each subtype was high, together with a significant difference among subtypes. It is necessary to strengthen the monitoring of different subtypes of drug resistant strains in China to prevent the recombination and spreading of resistant strains.
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