| 高文静,李立明.中国双生子队列研究进展[J].中华流行病学杂志,2017,38(6):828-831 |
| 中国双生子队列研究进展 |
| The Chinese national twin cohort:an update |
| 收稿日期:2017-02-04 出版日期:2017-06-19 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.06.027 |
| 中文关键词: 队列研究 双生子研究 |
| 英文关键词: Cohort study Twin study |
| 基金项目:公益性行业科研专项（201502006，201002007）；教育部科学技术研究重大项目（310006）；国家自然科学基金（81573223，81473041，81202264）；中华医学基金（01-746） |
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| 中文摘要: |
| 我国大型人群队列研究方兴未艾，双生子作为一种特殊人群，由于其同时出生、共享母体的宫内环境和早期家庭环境的天然对照优势，可以进行匹配的队列研究，从而很好地控制年龄、性别（同性别双生子）、遗传（同卵双生子）或早期环境（共同抚养的双生子）所带来的混杂，为慢性复杂性疾病病因研究提供不可多得的良好资源。本文将就中国双生子队列的目标、现状、挑战与机遇进行简要介绍，着重呈现双生子不同于一般人群队列的特征。 |
| 英文摘要: |
| The importance of large cohort studies in China has been increasingly emphasized. As special group in the population, twins provide excellent natural resources since they share the same birthday, maternal intrauterine environment and early family environment. Twin cohorts are unique for and benefit on controlling the confounding factors as age, gender (same-sex twins), genetic background (monozygotic twins) or early environment (being raised together) in the etiological studies on complex diseases. In this review, we briefly introduce the objectives, current situation, challenges and opportunities related to the Chinese national twin cohort, focusing on the characteristics of twins that are different from other groups in the general population. |
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