| 王上上,陈天娇,季成叶.儿童青少年注意问题和焦虑/抑郁相关遗传与环境因素影响的双生子研究[J].中华流行病学杂志,2017,38(9):1183-1186 |
| 儿童青少年注意问题和焦虑/抑郁相关遗传与环境因素影响的双生子研究 |
| A twin study of genetic and environmental influences on relationship between attention deficit and anxiety/depression in children and adolescents |
| 收稿日期:2017-01-16 出版日期:2017-09-09 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.09.008 |
| 中文关键词: 注意问题 焦虑/抑郁 遗传和环境 双生子 儿童青少年 |
| 英文关键词: Attention deficit Anxiety/depression Genetic and environmental factors Twin Children and adolescents |
| 基金项目:国家自然科学基金（81001249） |
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| 中文摘要: |
| 目的 探讨遗传和环境因素对儿童青少年注意问题和焦虑/抑郁关联的影响。方法 对1 062名同性别6~18岁双生子，采用Achenbach儿童行为量表家长用问卷进行调查。使用Mx软件拟合结构方程的单变量模型。构建Cholesky分解模型分析注意问题和焦虑/抑郁中的遗传和环境影响相关。结果 注意问题与焦虑/抑郁有遗传相关（rg=0.48），共享环境因素相关作用为0.86，非共享环境因素相关作用为0.14。结论 遗传因素和共享环境因素对注意问题和焦虑/抑郁的相关起重要作用，非共享环境因素对相关所起作用较小。 |
| 英文摘要: |
| Objective To understand the genetic and environmental influences on the relationship between attention deficit and anxiety/depression in children and adolescents. Methods A total of 1 062 same-sex twins aged 6-18 years were included in this study. A parent-rated child behavior checklist (CBCL) was used in the assessment. Software Mx was used to fit the univariate model of structural equation. The relationship between attention deficit and anxiety/depression was analyzed through bivariate genetic modeling. Results The genetic factor had influence on the relationship between attention deficit and anxiety/depression (rg=0.48). Shared and non-shared environmental correlation scores of attention deficit and anxiety/depression were 0.86 and 0.14 respectively. Conclusion Common genetic and shared environmental influences can explain the relationship between attention deficit and anxiety/depression in children and adolescents. |
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