妊娠期高血压疾病与早期儿发生关联的出生队列研究

李飞扬; 严双琴; 黄锟; 毛雷婧; 潘维君; 葛星; 韩艳; 郝加虎; 陶芳标

文章摘要

李飞扬,严双琴,黄锟,毛雷婧,潘维君,葛星,韩艳,郝加虎,陶芳标.妊娠期高血压疾病与早期儿发生关联的出生队列研究[J].中华流行病学杂志,2017,38(12):1603-1606

妊娠期高血压疾病与早期儿发生关联的出生队列研究

Relations between hypertensive disorders in pregnancy and subsequent risk of early-term birth: a birth cohort study

收稿日期:2017-04-30 出版日期:2017-12-26

DOI：10.3760/cma.j.issn.0254-6450.2017.12.003

中文关键词: 高血压,妊娠性先兆子痫早期儿 logistic模型

英文关键词: Hypertension,pregnancy-induced Pre-eclampsia Early-term birth Logistic models

基金项目:国家自然科学基金（81330068，81573168）

作者	单位	E-mail
李飞扬	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
严双琴	243000 马鞍山市妇幼保健计划生育服务中心
黄锟	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
毛雷婧	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
潘维君	243000 马鞍山市妇幼保健妇产科
葛星	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
韩艳	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
郝加虎	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室
陶芳标	230032 合肥, 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系人口健康与优生安徽省重点实验室	fbtao@ahmu.edu.cn

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中文摘要:

目的研究妊娠期高血压疾病（HDP）对早期儿发生的影响。方法纳入参与出生队列研究的3 474名孕妇，在孕早期收录基础人口学信息，并在孕早、中和晚期诊断HDP。在准确评定孕周的基础上，将孕周37~38⁺⁶界定为早期儿。采用多项logistic回归方法，分析HDP中妊娠期高血压及子痫前期与早期儿发生关联及其强度。结果共3 260名孕妇纳入分析，HDP发生率为6.0%（n=194），妊娠期高血压和子痫前期的发生率分别为4.2%（n=137）和1.8%（n=57）。控制混杂因素后，HDP中妊娠期高血压与早期儿发生无统计学关联（OR=1.49，95% CI：0.94~2.36）；子痫前期可增加早期儿发生风险（OR=4.46，95% CI：2.09~9.54）。结论子痫前期显著增加早期儿发生风险，早期发现和干预对降低早期儿的发生风险有重大意义。

英文摘要:

Objective To evaluate the relations between hypertensive disorders (HDP) in pregnancy and early-term birth.Methods A total of 3 474 pregnant women were consecutively recruited. Demographic information was collected in early pregnancy. HDP was diagnosed in the first, second and third trimesters, respectively. On the basis of precise evaluation on gestation age, early-term birth was defined as gestational age of 37-38 weeks+6 days. Logistic regression models were conducted to examine the associations between HDP and early-term birth.Results The current study included 3 260 pregnant women, with the rates of HDP, pregnancy-induced hypertension syndrome and pre-eclampsia as 6.0% (n=194), 4.2% (n=137) and 1.8% (n=57), respectively. After controlling for potential confounders, no significant differences between pregnancy-induced hypertension syndrome and early-term birth (OR=1.49, 95% CI:0.94-2.36) were found. Pre-eclampsia appeared to have increased the risk of early-term birth (OR=4.46, 95% CI:2.09-9.54).Conclusion Pre-eclampsia could significantly increase the risk of early-term birth. This finding suggested that early detection and intervention programs were helpful in reducing the risk of early-term birth.

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