文章摘要
段鹭茜,李杏莉,胡佩武,罗芮,罗希,陈颖怡.DRD2基因多态性与美沙酮维持治疗剂量的关联性研究[J].中华流行病学杂志,2018,39(2):194-198
DRD2基因多态性与美沙酮维持治疗剂量的关联性研究
Association between DRD2 gene polymorphisms and the dosage used on methadone maintenance treatment program
收稿日期:2017-08-10  出版日期:2018-02-10
DOI:10.3760/cma.j.issn.0254-6450.2018.02.011
中文关键词: 美沙酮维持治疗;DRD2基因;单核苷酸多态性;治疗剂量
英文关键词: Methadone maintenance treatment;DRD2 gene;Single nucleotide polymorphism;Treatment dose
基金项目:国家自然科学基金(81202257);中南大学教师研究基金(2013JSJJ032);教育部留学回国人员科研启动基金
作者单位E-mail
段鹭茜 410078 长沙, 中南大学湘雅公共卫生学院流行病与卫生统计学教研室  
李杏莉 410078 长沙, 中南大学湘雅公共卫生学院流行病与卫生统计学教研室 lixingli@csu.edu.cn 
胡佩武 410008 长沙, 中南大学湘雅医院科研部  
罗芮 410078 长沙, 中南大学湘雅公共卫生学院流行病与卫生统计学教研室  
罗希 410078 长沙, 中南大学湘雅公共卫生学院流行病与卫生统计学教研室  
陈颖怡 410078 长沙, 中南大学湘雅公共卫生学院流行病与卫生统计学教研室  
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中文摘要:
      目的 探讨DRD2基因的3个单核苷酸多态性位点(rs1800497、rs6275以及rs1799978)与美沙酮维持治疗剂量之间的关联。方法 采用病例对照研究的方法,使用Quanto软件估算样本量至少180人。实际共纳入美沙酮维持治疗者257人,其中低剂量对照组89人,高剂量病例组168人。收集研究对象的一般情况、既往吸毒状况以及服药状况等信息,并对其进行DRD2基因分型,以探讨DRD2基因的多态性与美沙酮维持治疗剂量的关联性。结果 DRD2基因rs6275位点基因型在不同美沙酮维持治疗剂量组间的分布差异有统计学意义,TC基因携带者相比于TT基因携带者(OR=0.338,95% CI:0.115~0.986),TC+CC基因型携带者相比于TT基因型携带者(OR=0.352,95% CI:0.127~0.975)可能需要更低的美沙酮维持治疗剂量。尚未发现rs6275位点的等位基因,rs1800497位点、rs1799978位点的等位基因以及各遗传模型下的基因型在不同美沙酮治疗剂量组间分布的差异有统计学意义。结论 DRD2基因rs6275位点与美沙酮维持治疗剂量有关联。尚未发现rs1800497位点、rs1799978位点与美沙酮维持治疗剂量有关联。
英文摘要:
      Objective To investigate the association between three single nucleotide polymorphism (SNP) genes DRD2 (rs1800497, rs6275, and rs1799978) and the dosage used on methadone maintenance treatment (MMT). Methods From the methadone maintenance treatment centers, 257 MMT patients were recruited to participate in a case-control study and divided into two groups-control groups under low dosage (n=89) and case (n=168) group with high dosage. Quanto software was used to estimate the sample size as 180. Information related to social-demographic status, history on drug use and medication were collected. And DRD2 SNPs were genotyped to explore the relationship between polymorphism of DRD2 gene and the dosage of methadone maintenance treatment. Results Distributions of DRD2 rs6275 between different groups were significantly different. Patients carrying TC genotype needed lower dose of methadone when compared to the patients that carrying CC genotype counterparts (OR=0.338, 95% CI:0.115-0.986). Patients that carrying C allele at rs6275 needed lower methadone dose than those that carrying genotype TT (OR=0.352, 95% CI:0.127-0.975). Distributions of genotypes, alles in the other two SNPs (rs1800497, rs1799978) were not significantly different between groups under different dosages. Conclusion DRD2 rs6275 was associated with dosage of methadone used for the MMT patients. However, no significant associations were found between rs1800497, rs1799978 and the dosage of methadone.
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