文章摘要
王茜,李木丽,陈叶,王冰,陶晓燕,朱武洋.中国不同地区狂犬病病毒种群分布的差异[J].中华流行病学杂志,2018,39(4):491-494
中国不同地区狂犬病病毒种群分布的差异
Differences on geographic distribution of rabies virus lineages in China
收稿日期:2017-08-08  出版日期:2018-04-18
DOI:10.3760/cma.j.issn.0254-6450.2018.04.021
中文关键词: 狂犬病  狂犬病病毒  种群  流行  分布
英文关键词: Rabies  Rabies virus  Lineage  Epidemic  Distribution
基金项目:国家重点研发计划(2016YFD0500400);国家自然科学基金(31500152)
作者单位E-mail
王茜 102206 北京, 中国疾病预防控制中心病毒病预防控制所  
李木丽 518020 深圳市人民医院病理科  
陈叶 110031 沈阳市疾病预防控制中心  
王冰 110031 沈阳市疾病预防控制中心  
陶晓燕 102206 北京, 中国疾病预防控制中心病毒病预防控制所 txy212@126.com 
朱武洋 102206 北京, 中国疾病预防控制中心病毒病预防控制所 zhuwuyang1971@sina.com 
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中文摘要:
      目的 明确我国不同地区流行的狂犬病病毒种群类别及其流行特征。方法 汇总GenBank数据库所有中国狂犬病流行株的N、G和全基因组序列以及国家狂犬病实验室新测定毒株序列,分别构建N基因和G基因种系发生树,明确每个毒株的种群归属。统计各地区流行株的种群类别及不同种群的毒株数量。结果 全国共流行6个毒株群(ChinaⅠ~Ⅵ),云南和湖南是我国大陆种群最丰富省份,均有多达4个群流行;河南、福建等6省份均有3个毒株群流行;上海、江西等8省份皆流行2个病毒种群;北京、天津等14省份目前只监测到1个毒株群流行。优势毒株群ChinaⅠ已蔓延至我国东北部和西部地区,共计覆盖25个省份;China Ⅲ群近年在内蒙古、新疆地区的野生动物中流行且溢出至家畜中;China Ⅳ是青海、西藏地区的流行种群,同时流行于内蒙古、黑龙江地区的野生动物中。结论 我国不同地区狂犬病病毒种群类别和数量差异明显。
英文摘要:
      Objective To study the lineages of rabies virus and the epidemic characteristics in different provincial populations of China, to provide information for the development of control and prevention measures in each respective provinces. Methods Full length N and G genes and full-genome of epidemic strains of rabies virus collected in China were downloaded from GenBank and combined with newly sequenced strains by our lab. Each strain was classified under six lineages of China rabies by constructing phylogenetic trees based on the N or G sequences. Numbers of strains and lineages in each province were counted and compared. Results Six lineages (China Ⅰ-Ⅵ) were prevalent in China, with 4 found in Yunnan and Hunan. In 6 provinces, including Henan and Fujian, 3 lineages were found. In 8 provinces, including Shanghai and Jiangxi, 2 lineages were found Only 1 lineage, were found in Beijing, Tianjin and other 12 provinces. the China Ⅰ, was the dominant one in 25 provinces. In recent years, China Ⅲ had been found in wild animals and spread over livestock in Inner Mongolia and Xinjiang areas. Qinghai and Tibet had been influenced by China Ⅳ, which also been found in wild animals of Inner Mongolia and Heilongjiang. Conclusion There had been obvious differences in lineages and strain numbers of rabies virus identified in different provinces in China.
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