文章摘要
殷召雪,任泽萍,荆刚,刘丹,张坚,王卓群,张梅,翟屹,宋鹏坤,赵艳芳,庞邵杰,米生权,赵文华.老年人肾健康相关膳食模式与认知障碍关系的队列研究[J].中华流行病学杂志,2019,40(4):427-432
老年人肾健康相关膳食模式与认知障碍关系的队列研究
A cohort study on the association between dietary patterns which benefit for normal kidney function and the cognitive performance in the Chinese elderly
投稿时间:2018-09-27  
DOI:10.3760/cma.j.issn.0254-6450.2019.04.011
中文关键词: 膳食模式;认知功能;降秩回归;肾功能
英文关键词: Dietary pattern;Cognitive function;Reduced rank regression;Kidney function
基金项目:中国疾病预防控制中心公共卫生应急反应机制的运行(131031001000150001);全国农村基层卫生服务机构老年人营养支持能力建设项目
作者单位E-mail
殷召雪 中国疾病预防控制中心慢性病防治与社区卫生处, 北京 102206  
任泽萍 山西省疾病预防控制中心慢病所, 太原 030012  
荆刚 山西省临猗县疾病预防控制中心, 临猗 044100  
刘丹 中国疾病预防控制中心营养与健康所, 北京 100050  
张坚 中国疾病预防控制中心营养与健康所, 北京 100050  
王卓群 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
张梅 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
翟屹 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心, 北京 100070  
宋鹏坤 中国疾病预防控制中心营养与健康所, 北京 100050  
赵艳芳 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
庞邵杰 国家粮食局科学研究院粮食品质营养研究所, 北京 100037  
米生权 北京联合大学健康与环境学院 100101  
赵文华 中国疾病预防控制中心营养与健康所, 北京 100050 zhaowh@chinacdc.cn 
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中文摘要:
      目的 研究肾健康相关膳食模式与老年人认知下降和认知受损发生风险之间的关系。方法 选取山西营养与慢性病家庭队列4个县(区)2015年≥ 60岁的老年人为研究对象,2017年进行随访,采用简易心理状况量表再次评估认知功能及其变化。采用降秩回归法提取肾健康相关膳食模式,采用多因素logistic回归模型,分析肾健康相关膳食模式评分与2年后认知功能下降风险之间的关系,并分析2015年认知功能正常者中肾健康相关膳食模式评分与2年后认知受损发生风险之间的关系。结果 肾健康相关膳食模式的主要特点是谷物、蔬菜、杂豆类和水果摄入较多,而肉类、大豆制品等食物摄入较少。与该模式评分的<P33.3组相比,≥ P66.6组研究对象2年后认知功能下降的风险明显较低(OR=0.57,95% CI:0.37~0.85),差异有统计学意义(P<0.01),且具有显著的线性趋势(P=0.007)。在2015年认知功能正常者中,该模式评分≥ P66.6组研究对象2年后认知受损发生的风险也明显较低(OR=0.52,95% CI:0.29~0.93),差异有统计学意义(P<0.05),而且各组风险具有显著的线性下降趋势(P=0.01)。结论 肾健康相关膳食模式评分与认知下降和认知受损发生风险均呈明显负相关。
英文摘要:
      Objective To explore the association between dietary pattern which benefit for normal kidney function and the risk of cognitive decline or impairment in the elderly. Methods In 2015, subjects aged 60 and over from four counties in the Nutrition and Chronic Disease Family Cohort project, were followed up in 2017. Cognitive function was repeatedly assessed, using the Mini Mental State Evaluation (MMSE) scale. Dietary pattern that benefit for normal kidney function was extracted, using the reduced rank regression method and followed by logistic regression models to explore the associations between scores that showing the kidney function on dietary patterns and the risk of cognitive deterioration and impairment in two years among those who were with normal cognition in 2015. Results Dietary pattern that benefit for normal kidney function, was characterized by high consumption of cereal, vegetables, legume and fruits but with less meat and soy products. Comparing with the group with lowest score quartile on this dietary pattern, the risk of cognitive deterioration in the highest quartile group was significantly low (P<0.01) in two years, with an odds ratio as 0.57 (95% CI:0.37-0.85). Linear trend was also obviously visible (P=0.007) in this group. The ones at the highest quartile group among the normal cognition ones in 2015, the risk of cognitive impairment also significantly reduced (P<0.05) in two years time, with an odds ratio as 0.52 (95% CI:0.29-0.93). Also, linear trend could obviously be seen (P=0.01). Conclusion Dietary pattern that benefit for normal kidney function was both inversely associated with cognitive deterioration and impairment, in two years.
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