文章摘要
李敏敏,李超,张彬艳,武文涛,高翔宇,吴晨璐,党少农,颜虹.陕西省育龄妇女围孕期用药与新生儿早产关系的研究[J].中华流行病学杂志,2019,40(5):554-558
陕西省育龄妇女围孕期用药与新生儿早产关系的研究
Relationship between preterm birth of infant and medication during pregnancy in women of childbearing age in Shaanxi
投稿时间:2018-10-22  
DOI:10.3760/cma.j.issn.0254-6450.2019.05.012
中文关键词: 早产;孕期;药物
英文关键词: Preterm birth;Pregnancy;Medicine
基金项目:国家自然科学基金(81230016);陕西省卫生和计划生育委员会出生缺陷防治课题(sxwsjswzfcght 2016-013)
作者单位E-mail
李敏敏 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
李超 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
张彬艳 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
武文涛 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
高翔宇 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
吴晨璐 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
党少农 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061 tjdshn@mail.xjtu.edu.cn 
颜虹 西安交通大学医学部公共卫生学院流行病与卫生统计学系 710061  
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中文摘要:
      目的 探讨陕西地区育龄妇女围孕期用药与活产单胎新生儿早产的关系。方法 采用分层多阶段随机抽样方法,以问卷调查方式收集2010-2013年陕西省怀孕且结局明确的育龄妇女及其子女的相关信息。计数资料采用百分比描述,计量资料采用x±s描述,用多阶段复杂抽样logistic回归分析围孕期用药与新生儿早产的关系。结果 陕西省活产单胎新生儿早产的发生率为2.7%。在28 841例调查对象中,围孕期用药者占15.8%。妇女围孕期使用最多的药物为感冒药1 702例(5.9%)。在控制混杂因素后,围孕期服用激素类药物者新生儿早产的发生率是未服用者的2.23倍(OR=2.23,95% CI:1.19~4.18)、服用抗高血压药者是未服用者的7.74倍(OR=7.74,95% CI:4.28~13.95)、服用其他药物者是未服用者的2.15倍(OR=2.15,95% CI:1.60~2.89)。结论 陕西省育龄妇女围孕期服用激素类、抗高血压和其他药物会增加早产的罹患风险。
英文摘要:
      Objective To understand the relationship between medication during pregnancy and single live preterm birth of infant in women of childbearing age in Shaanxi province. Methods A cross-sectional design was used in this study and stratified multistage random sampling method was used. A questionnaire survey was conducted in the childbearing-aged women selected through multi stage stratified random sampling in Shaanxi during 2010 to 2013. Qualitative datum was described by percentage and measurement datum was described by mean±standard deviation. Logistic regression analysis was done to evaluate the relationship between medication during pregnancy and preterm birth of infant. Results The overall incidence rate of premature birth was 2.7% in Shaanxi. Among the 28 841 mothers participating in this study, the proportion of medication use at any time during pregnancy was 15.8%, and the most commonly used drug was cold medicine (5.9%). After adjusting all confounding factors, the multivariable logistic regression analysis results showed that taking hormone medicine (OR=2.23, 95%CI:1.19-4.18), antihypertensive medicine (OR=7.74, 95%CI:4.28-13.95) and other medicines (OR=2.15, 95%CI:1.60-2.89) during early pregnancy were the risk factors for preterm delivery, the risk was 2.23 times, 7.74 times and 2.15 times higher compared with those taking no these medicines. Conclusion Using hormone medicine, antihypertensive medicine and other medicines during pregnancy increased the risk for preterm delivery in women of childbearing age in Shaanxi.
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