文章摘要
高慧,黄锟,伍晓艳,蔡秀秀,韩艳,朱鹏,郝加虎,陶芳标.学龄前儿童邻苯二甲酸酯暴露的累积风险评估[J].中华流行病学杂志,2019,40(5):585-589
学龄前儿童邻苯二甲酸酯暴露的累积风险评估
Cumulative risk assessment of phthalates exposure in preschool children
投稿时间:2018-09-21  
DOI:10.3760/cma.j.issn.0254-6450.2019.05.018
中文关键词: 邻苯二甲酸酯;学龄前儿童;累积暴露风险评估;危害指数
英文关键词: Phthalate;Preschool children;Cumulative risk assessment;Hazard index
基金项目:国家自然科学基金(81330068)
作者单位E-mail
高慧 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032  
黄锟 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032
人口健康与优生安徽省重点实验室, 合肥 230032 
 
伍晓艳 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032
人口健康与优生安徽省重点实验室, 合肥 230032 
 
蔡秀秀 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032  
韩艳 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032  
朱鹏 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032
人口健康与优生安徽省重点实验室, 合肥 230032 
 
郝加虎 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032
人口健康与优生安徽省重点实验室, 合肥 230032 
 
陶芳标 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032
人口健康与优生安徽省重点实验室, 合肥 230032 
fangbiaotao@126.com 
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中文摘要:
      目的 通过检测尿中邻苯二甲酸酯(PAEs)代谢物浓度,评估安徽省马鞍山市学龄前儿童累积暴露的健康风险。方法 基于中国-安徽出生队列,2014年4月至2015年4月在安徽省马鞍山市采集3 743名儿童的基本信息和随机尿样。采用固相萃取-三重四级杆高效液相色谱串联质谱-同位素稀释法检测尿中5种PAEs[邻苯二甲酸二甲酯(DMP);邻苯二甲酸二乙酯(DEP)和邻苯二甲酸二丁酯(DBP);邻苯二甲酸丁苄酯(BBzP);邻苯二甲酸单(2-乙基己)酯(DEHP)]的7种代谢物[邻苯二甲酸单甲酯(MMP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单苄酯(MBzP)、邻苯二甲酸单(2-乙基己)酯(MEHP)、邻苯二甲酸单(2-乙基-5-氧己基)酯(MEOHP)和邻苯二甲酸单(2-乙基-5-羟己基)酯(MEHHP)]浓度,根据代谢物浓度计算5种PAEs的每日估计暴露量。使用危害商(HQ)和危害指数(HI)法进行累积风险评估。结果 7种代谢物浓度MQR)分别为29.58(18.69~48.26)、26.65(13.44~56.09)、256.86(150.99~438.51)、0.12(0.04~0.32)、6.27(3.71~11.13)、17.94(11.94~28.42)和24.80(16.05~40.32)μg/g肌酐。5种PAEs的每日估计暴露量从高到低依次为DBP、DEHP、DMP、DEP和BBzP,M依次为7.54(4.41~12.85)、3.35(2.20~5.42)、0.75(0.47~1.24)、0.71(0.36~1.52)和0.003(0.001~0.009)μg/(kg·d)。不同月龄、性别和采样季节间的HQ和HI差异有统计学意义(P<0.05)。结论 马鞍山市3~6岁学龄前儿童PAEs累积暴露的健康风险较高,年龄、性别和季节是其影响因素。
英文摘要:
      Objective The urine concentrations of phthalate metabolites were used to estimate the cumulative risk assessment in preschool children in Ma'anshan of Anhui province. Methods Based on the China-Anhui Birth Cohort, the demographic information and urine samples of 3 743 children were collected in Ma'anshan from April 2014 to April 2015. The concentrations of 7 metabolites'[monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)] of 5 phthalates[dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBzP), and di (2-ethylhexyl) phthalate (DEHP)] in the urine samples of the children were measured by solid-phase extration-triple quadrupole high performance liquid chromatography-tandem mass spectrometry-isotope method. In addition, the estimated daily intakes (EDIs) of 5 phthalates were calculated according to the metabolites' concentrations. Cumulative risk assessment was performed using hazard quotient (HQ) and hazard index (HI) methods. Results The M (QR) of seven metabolite concentrations were 29.58 (18.69-48.26), 26.65 (13.44-56.09), 256.86 (150.99-438.51), 0.12 (0.04-0.32), 6.27 (3.71-11.13), 17.94 (11.94-28.42) and 24.80 (16.05-40.32) μg/g creatinine, respectively. For the EDIs of 5 phthalates, DBP ranked first, followed by DEHP, DMP, DEP and BBzP with the M (QR) of 7.54 (4.41-12.85), 3.35 (2.20-5.42), 0.75 (0.47-1.24), 0.71 (0.36-1.52) and 0.003 (0.001-0.009) μg/(kg·d), respectively. The HQ and HI varied with age, gender and sampling season, the differences were significant (P<0.05). Conclusions These results indicated that risk of cumulative exposure to phthalates was high in preschool children aged 3-6 years in Ma'anshan. Age, gender and sampling season were influencing factors.
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