高慧,黄锟,伍晓艳,蔡秀秀,韩艳,朱鹏,郝加虎,陶芳标.学龄前儿童邻苯二甲酸酯暴露的累积风险评估[J].中华流行病学杂志,2019,40(5):585-589 |
学龄前儿童邻苯二甲酸酯暴露的累积风险评估 |
Cumulative risk assessment of phthalates exposure in preschool children |
收稿日期:2018-09-21 出版日期:2019-05-17 |
DOI:10.3760/cma.j.issn.0254-6450.2019.05.018 |
中文关键词: 邻苯二甲酸酯 学龄前儿童 累积暴露风险评估 危害指数 |
英文关键词: Phthalate Preschool children Cumulative risk assessment Hazard index |
基金项目:国家自然科学基金(81330068) |
作者 | 单位 | E-mail | 高慧 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 | | 黄锟 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 人口健康与优生安徽省重点实验室, 合肥 230032 | | 伍晓艳 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 人口健康与优生安徽省重点实验室, 合肥 230032 | | 蔡秀秀 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 | | 韩艳 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 | | 朱鹏 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 人口健康与优生安徽省重点实验室, 合肥 230032 | | 郝加虎 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 人口健康与优生安徽省重点实验室, 合肥 230032 | | 陶芳标 | 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系, 合肥 230032 人口健康与优生安徽省重点实验室, 合肥 230032 | fangbiaotao@126.com |
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中文摘要: |
目的 通过检测尿中邻苯二甲酸酯(PAEs)代谢物浓度,评估安徽省马鞍山市学龄前儿童累积暴露的健康风险。方法 基于中国-安徽出生队列,2014年4月至2015年4月在安徽省马鞍山市采集3 743名儿童的基本信息和随机尿样。采用固相萃取-三重四级杆高效液相色谱串联质谱-同位素稀释法检测尿中5种PAEs[邻苯二甲酸二甲酯(DMP);邻苯二甲酸二乙酯(DEP)和邻苯二甲酸二丁酯(DBP);邻苯二甲酸丁苄酯(BBzP);邻苯二甲酸单(2-乙基己)酯(DEHP)]的7种代谢物[邻苯二甲酸单甲酯(MMP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单苄酯(MBzP)、邻苯二甲酸单(2-乙基己)酯(MEHP)、邻苯二甲酸单(2-乙基-5-氧己基)酯(MEOHP)和邻苯二甲酸单(2-乙基-5-羟己基)酯(MEHHP)]浓度,根据代谢物浓度计算5种PAEs的每日估计暴露量。使用危害商(HQ)和危害指数(HI)法进行累积风险评估。结果 7种代谢物浓度M(QR)分别为29.58(18.69~48.26)、26.65(13.44~56.09)、256.86(150.99~438.51)、0.12(0.04~0.32)、6.27(3.71~11.13)、17.94(11.94~28.42)和24.80(16.05~40.32)μg/g肌酐。5种PAEs的每日估计暴露量从高到低依次为DBP、DEHP、DMP、DEP和BBzP,M依次为7.54(4.41~12.85)、3.35(2.20~5.42)、0.75(0.47~1.24)、0.71(0.36~1.52)和0.003(0.001~0.009)μg/(kg·d)。不同月龄、性别和采样季节间的HQ和HI差异有统计学意义(P<0.05)。结论 马鞍山市3~6岁学龄前儿童PAEs累积暴露的健康风险较高,年龄、性别和季节是其影响因素。 |
英文摘要: |
Objective The urine concentrations of phthalate metabolites were used to estimate the cumulative risk assessment in preschool children in Ma'anshan of Anhui province. Methods Based on the China-Anhui Birth Cohort, the demographic information and urine samples of 3 743 children were collected in Ma'anshan from April 2014 to April 2015. The concentrations of 7 metabolites'[monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)] of 5 phthalates[dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBzP), and di (2-ethylhexyl) phthalate (DEHP)] in the urine samples of the children were measured by solid-phase extration-triple quadrupole high performance liquid chromatography-tandem mass spectrometry-isotope method. In addition, the estimated daily intakes (EDIs) of 5 phthalates were calculated according to the metabolites' concentrations. Cumulative risk assessment was performed using hazard quotient (HQ) and hazard index (HI) methods. Results The M (QR) of seven metabolite concentrations were 29.58 (18.69-48.26), 26.65 (13.44-56.09), 256.86 (150.99-438.51), 0.12 (0.04-0.32), 6.27 (3.71-11.13), 17.94 (11.94-28.42) and 24.80 (16.05-40.32) μg/g creatinine, respectively. For the EDIs of 5 phthalates, DBP ranked first, followed by DEHP, DMP, DEP and BBzP with the M (QR) of 7.54 (4.41-12.85), 3.35 (2.20-5.42), 0.75 (0.47-1.24), 0.71 (0.36-1.52) and 0.003 (0.001-0.009) μg/(kg·d), respectively. The HQ and HI varied with age, gender and sampling season, the differences were significant (P<0.05). Conclusions These results indicated that risk of cumulative exposure to phthalates was high in preschool children aged 3-6 years in Ma'anshan. Age, gender and sampling season were influencing factors. |
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