文章摘要
张雨格,吴晶,封磊,袁剑敏,许恩佩,潘安.中年含糖饮料摄入频率与老年认知障碍的关系[J].中华流行病学杂志,2020,41(1):55-61
中年含糖饮料摄入频率与老年认知障碍的关系
Sugar-sweetened beverages consumption in midlife and risk of late-life cognitive impairment in Chinese adults
收稿日期:2019-03-26  出版日期:2020-01-14
DOI:10.3760/cma.j.issn.0254-6450.2020.01.011
中文关键词: 含糖饮料;认知障碍;队列研究
英文关键词: Sugar-sweetened beverages;Cognitive impairment;Cohort study
基金项目:国家重点研发计划(2017YFC0907504);新加坡卫生部(NMRC/CSA/0055/2013);美国国立卫生研究院(UM1 CA182876,R01 CA144034)
作者单位E-mail
张雨格 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室, 武汉 430030 
 
吴晶 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室, 武汉 430030 
 
封磊 新加坡国立大学杨潞龄医学院医学心理学系 119228  
袁剑敏 美国匹兹堡大学希尔曼癌症中心 15232
美国匹兹堡大学公共卫生学院流行病学系 15261 
 
许恩佩 杜克-新加坡国立大学医学院卫生服务体系研究中心 169857
新加坡国立大学苏瑞福公共卫生学 院 117549 
woonpuay.koh@duke-nus.edu.sg 
潘安 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系, 武汉 430030
华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室, 武汉 430030 
panan@hust.edu.cn 
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中文摘要:
      目的 探究中年时期含糖饮料摄入频率与老年认知障碍风险的关系。方法 对来自新加坡华族健康队列的16 948名研究对象进行16~23年(平均20年)的随访,研究对象的含糖饮料摄入信息于基线调查获得(1993-1998年),研究对象的认知状态通过第3次随访期间(2014-2016年)在新加坡人群中校正过的简易智力状态检查量表获得。采用多元logistic线性回归模型分析含糖饮料摄入频率与认知障碍风险的关系。结果 在纳入的研究对象中,2 443名存在认知障碍。在控制了年龄、性别、籍贯、文化程度、生活方式(包括饮食因素)和疾病信息后,含糖饮料摄入频率与认知障碍风险关联无统计学意义。与几乎不喝碳酸饮料组相比,每周摄入碳酸饮料≥ 2次(OR=0.91,95%CI:0.77~1.08)、每周摄入1次(OR=1.00,95%CI:0.82~1.23)和每月摄入1~3次(OR=0.94,95%CI:0.80~1.09)的研究对象认知障碍发生风险差异无统计学意义(趋势性P=0.306)。与几乎不喝果(蔬)汁组相比,每周摄入果(蔬)汁≥ 2次(OR=1.03,95%CI:0.88~1.20)、每周摄入1次(OR=0.96,95%CI:0.82~1.12)和每月摄入1~3次(OR=0.94,95%CI:0.82~1.08)的研究对象的认知障碍发生风险均无统计学差异(趋势性P=0.930)。分层分析及敏感性分析对研究结果都没有实质改变。结论 在平均含糖饮料摄入频率较低的新加坡籍华人中,中年时期含糖饮料摄入频率与老年认知障碍风险差异无统计学意义。
英文摘要:
      Objective To evaluate whether midlife consumption of sugar-sweetened beverages (SSBs), including juices and soft drinks, were associated with late-life cognitive impairment in Chinese adults. Methods Follow up was conducted for participants from Singapore Chinese Health Study, a population-based prospective cohort, for 16-23 (mean 20) years. The information about their SSBs consumption were collected at baseline survey from 1993 to 1998 by using a validated food frequency questionnaire and their cognition status were evaluated by using a Singapore-modified Mini-Mental State Examination Scale in the 3rd follow-up visit during 2014-2016. Multivariable logistic regression models were used to estimate the ORs and 95%CIs. Results A total of 16 948 participants were included in the analysis and 2 443 of them were identified as cognitive impairment using education-specific cutoffs. Sex, age, ancestral home, education level, physical activity level, total diet fiber intake level, BMI, alcohol drinking were significantly associated with cognitive impairment (P<0.05). After adjusted the above variables, potential dietary variables and disease status, no significant association was observed between SSBs consumption and cognitive impairment (P>0.05). Compared with those who never or hardly ever drank soft drinks, no significant differences in cognitive impairment risk were observed for those who drank soft drinks 2 or more times a week (OR=0.91, 95%CI:0.77-1.08), those who drank 1 time a week (OR=1.00, 95%CI:0.82-1.23) and those who drank 1-3 times a month (OR=0.94, 95%CI:0.80-1.09) (trend P=0.306). Compared with those who never or hardly ever drank juices, no significant differences in cognitive impairment risk were observed for those who drank juices 2 or more times a week (OR=1.03, 95%CI:0.88-1.20), those who drank 1 time a week (OR=0.96, 95%CI:0.82-1.12) and those who drank 1-3 times a month (OR=0.94, 95%CI:0.82-1.08) (trend P=0.930). No significant interactions were found with age, sex, and BMI status. Conclusion SSBs consumption in midlife was not significantly associated with risk of late-life cognitive impairment in Singaporean Chinese adults with relatively low consumption levels. Further researches are needed to verify the results.
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