睡眠与冠心病的孟德尔随机化因果关联研究

高雪; 杨晓晨; 孟玲先; 孙鹤立; 王彤

文章摘要

高雪,杨晓晨,孟玲先,孙鹤立,王彤.睡眠与冠心病的孟德尔随机化因果关联研究[J].中华流行病学杂志,2020,41(4):611-614

睡眠与冠心病的孟德尔随机化因果关联研究

Causal relationship between sleep and coronary artery disease: a Mendelian randomization study

收稿日期:2019-06-24 出版日期:2020-04-24

DOI：10.3760/cma.j.cn112338-20190624-00462

中文关键词: 冠心病睡眠孟德尔随机化

英文关键词: Coronary artery disease Sleep Mendelian randomization

基金项目:国家自然科学基金（81872715）；山西省研究生教育创新项目（2019SY268）

作者	单位	E-mail
高雪	山西医科大学公共卫生学院卫生统计教研室, 太原 030001
杨晓晨	中国人民大学统计学院生物与医学统计学教研室, 北京 100872
孟玲先	山西医科大学公共卫生学院卫生统计教研室, 太原 030001
孙鹤立	山西医科大学公共卫生学院卫生统计教研室, 太原 030001
王彤	山西医科大学公共卫生学院卫生统计教研室, 太原 030001	tongwang@sxmu.edu.cn

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中文摘要:

目的对睡眠与冠心病之间的因果关联进行研究与探讨。方法研究包含5个睡眠相关性状[睡眠时间(连续变量)、长睡眠时间(二分类变量)、短睡眠时间(二分类变量)、早睡早起睡眠习惯、经常性失眠]的全基因组关联分析(GWAS)数据集与1个冠心病GWAS数据集。应用非独立工具变量异质性检测方法评估并排除无效工具变量,利用基于广义的汇总数据孟德尔随机化方法估计睡眠与冠心病之间的因果效应, 应用Bonferroni法校正检验的显著性水平。结果睡眠时间与冠心病具有显著的因果关联 (OR=0.755,95%CI:0.658~0.867,P=6.68E-05)。短睡眠时间(OR=4.251,95%CI:2.396~7.541,P=7.51E-07)以及经常性失眠 (OR=1.814,95%CI:1.346~2.446,P=9.25E-05)均会显著增加冠心病患病风险。而长睡眠时间以及早睡早起睡眠习惯与冠心病的因果关联不显著。结论睡眠时间以及经常性失眠与冠心病存在因果关联。

英文摘要:

Objective To understand the causal relationship between sleep and coronary artery disease (CAD). Methods This study included six genome-wide association parts; five for sleep related traits[sleep duration (continuous variable), long sleep duration (binary variable), short sleep duration (binary variable), early-to-bed/up habit (known as ‘morningness’) and frequently insomnia] and one for CAD. Heterogeneity in dependent instrument approach was used to assess and to remove the pleiotropic instruments. Generalized summary data-based Mendelian randomization was performed to estimate the causal relationships between sleep related traits and CAD. And a conservative Bonferroni was used for statistical tests. Results Sleep duration was putatively causal for CAD (OR=0.755, 95%CI:0.658-0.867, P=6.68E-05). Our results also indicated significant causal effects between both short sleep duration and frequently insomnia on CAD, with ORs as 4.251 (95%CI:2.396-7.541, P=7.51E-07) and 1.814 (95%CI:1.346-2.446, P=9.25E-05), respectively. There was no convincing evidence of causality between long sleep duration or morningness with CAD. Conclusions Our findings suggested that both sleep duration and frequently insomnia played causal roles on CAD, indicating that disease models should include sleep duration and insomnia as potential factors for CAD to develop effective interventions.

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