文章摘要
付凯钰,乔峰,孟革,张卿,刘莉,宋崑,牛凯军.缺失牙数与非酒精性脂肪肝的相关研究[J].中华流行病学杂志,2020,41(5):716-721
缺失牙数与非酒精性脂肪肝的相关研究
Association between tooth missing and non-alcoholic fatty liver disease
收稿日期:2019-06-21  出版日期:2020-05-12
DOI:10.3760/cma.j.cn112338-20190621-00457
中文关键词: 非酒精性脂肪肝;缺失牙;牙周炎
英文关键词: Non-alcoholic fatty liver disease;Tooth missing;Periodontal disease
基金项目:天津市科技支撑计划重点项目(11ZCGYSY05700,12ZCZDSY20400,13ZCZDSY20200,15YFYZSY00020)
作者单位E-mail
付凯钰 天津医科大学研究生院 300070  
乔峰 天津医科大学营养流行病学研究所 公共卫生学院 300070  
孟革 天津医科大学营养流行病学研究所 公共卫生学院 300070  
张卿 天津医科大学营养流行病学研究所 公共卫生学院 300070  
刘莉 天津医科大学营养流行病学研究所 公共卫生学院 300070  
宋崑 天津医科大学营养流行病学研究所 公共卫生学院 300070  
牛凯军 天津医科大学营养流行病学研究所 公共卫生学院 300070
天津医科大学总医院健康管理中心 300052 
nkj0809@163.com 
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中文摘要:
      目的 评价成年人群中缺失牙的数量和非酒精性脂肪肝(NAFLD)之间的关联。方法 对26 983名来源于天津营养流行病学队列(TCLSIH研究)的成年人进行横断面研究。根据缺失牙数(第三磨牙除外),分为0、1~、3~和≥ 6颗4组。NAFLD的诊断采用腹部超声检查和ALT测定,采用logistic回归分析成年人中缺失牙数与NAFLD之间的关系。结果 NAFLD患病人数为7 270人,至少有1颗牙缺失的人数为9 667人。经调整混杂因素后,根据缺失牙数从少到多(0、1~、3~和≥ 6颗)各组中,人群NAFLD患病的OR值(95% CI)分别为:男性1.00、1.04(0.93~1.15)、1.08(0.93~1.26)和1.38(1.09~1.76)(趋势检验P=0.030);女性1.00、0.96(0.82~1.12)、1.11(0.91~1.35)和1.22(0.90~1.64)(趋势检验P=0.450)。结论 男性缺失牙的数目≥ 6颗与NAFLD的高患病率相关,女性中无显著相关性。
英文摘要:
      Objective To evaluate the association between the number of teeth missed and the prevalence of non-alcoholic fatty liver disease (NAFLD) in adults. Methods A cross-sectional study was carried out in 26 983 adults from Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. The number of teeth missed (excluding third molars) was recorded and classified into four categories:0, 1-, 3- and ≥ 6. NAFLD was diagnosed by at least two liver ultrasonography examinations. Adjusted multivariable logistic regression analysis was used to access the association between the number of missed teeth and NAFLD in adults. Results The overall prevalence of NAFLD was 7 270 and the number of the subjects with at least one tooth missed was 9 667. The multivariable-adjusted ORs (95%CI) of NAFLD across the categories of tooth missing (0, 1-, 3- and ≥ 6) were as follows:1.00, 1.04 (0.93-1.15), 1.08 (0.93-1.26) and 1.38 (1.09-1.76) (trend test P=0.030) in males; 1.00, 0.96 (0.82-1.12), 1.11 (0.91-1.35) and 1.22 (0.90-1.64) (trend test P=0.450) in females. Conclusion The number of missed teeth was positively associated with a higher prevalence rate of NAFLD in males with over 6 teeth missed, but not in females.
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