文章摘要
杜松楠,王占军,于高娃,崔焱岭,陈俊杰,胡楠,张天承,孟颖,胡玉红,张慧超,刘志国.内蒙古自治区通辽市2004-2018年人间布鲁氏菌病流行病学特征分析[J].中华流行病学杂志,2020,41(7):1063-1067
内蒙古自治区通辽市2004-2018年人间布鲁氏菌病流行病学特征分析
Epidemiological characteristics of human brucellosis in Tongliao city of Inner Mongolia Autonomous Region, 2004-2018
收稿日期:2019-09-01  出版日期:2020-07-15
DOI:10.3760/cma.j.cn112338-20190901-00642
中文关键词: 人间布鲁氏菌病;流行病学;羊种布鲁氏菌;通辽市
英文关键词: Human brucellosis;Epidemiological characteristics;Brucella melitensis;Tongliao city
基金项目:内蒙古自治区自然科学基金(2018MS08004);内蒙古自治区卫生和计划生育委员会科研计划(201702154)
作者单位E-mail
杜松楠 内蒙古自治区通辽市地方病防治站 028000  
王占军 内蒙古自治区通辽市地方病防治站 028000  
于高娃 内蒙古自治区通辽市地方病防治站 028000  
崔焱岭 内蒙古自治区通辽市地方病防治站 028000  
陈俊杰 内蒙古自治区通辽市地方病防治站 028000  
胡楠 内蒙古自治区通辽市地方病防治站 028000  
张天承 内蒙古自治区通辽市地方病防治站 028000  
孟颖 内蒙古自治区通辽市地方病防治站 028000  
胡玉红 内蒙古自治区通辽市地方病防治站 028000  
张慧超 内蒙古自治区通辽市地方病防治站 028000  
刘志国 中国疾病预防控制中心传染病预防控制所, 北京 102206
内蒙古自治区综合疾病预防控制中心, 呼和浩特 010031 
liuzhiguo@icdc.cn 
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中文摘要:
      目的 分析内蒙古自治区通辽市2004-2018年人间布鲁氏菌病(布病)流行特点和菌株的起源与进化特征,为制定布病防控策略提供依据。方法 对中国疾病预防控制信息系统中的通辽市布病报告数据进行分析,采用构成比和率描述流行病学特征。用常规鉴定方法鉴定菌株的种型,用AMOS-PCR对菌株的种型进行复核,采用多位点可变数目串联重复序列分析(MLVA)对布鲁氏菌进行聚类分析,探讨菌株间的亲缘关系。结果 2004-2018年通辽市共报告布病16 704例,年均发病率为35.41/10万。扎鲁特旗和库伦旗的发病率较高,分别为110.51/10万和67.84/10万。40~54岁年龄组病例最多,占48.75%(8 143/16 704);农民14 873例,占89.04%。男女性别比为2.40:1。3-5月为发病高峰期,占56.30%(9 405/16 704),发病高峰在4月。常规鉴定表明临床分离菌株全部为羊种布鲁氏菌,羊1型3株,羊3型3株。AMOS-PCR鉴定显示全部为羊种布鲁氏菌。6株布鲁氏菌分为2个MLVA-11基因型(111和116),属于东地中海血统。MLVA-16聚类分析表明通辽地区的菌株与吉林省和黑龙江省的菌株具有较近的亲缘关系。结论 2004-2018年通辽市布病疫情极为严重,有向周边地区蔓延的风险。应加强检测防控,防止疫情扩散。
英文摘要:
      Objective To analyze the epidemiological characteristics of human brucellosis (HB), evolution and origin feature of Brucella strains in Tongliao city, Inner Mongolia Autonomous Region during 2004-2018, and to provide evidence for strategy development against the disease. Methods Data from the reports on HB in Tongliao during 2004-2018 were extracted from the China Information System for Disease Control and Prevention before being analyzed with software Excel 2016. Epidemiologic feature was described, using the number of cases, constituent ratio and related rates. Conventional biotypes methods were used for identification of species/biovars strains while species of six Brucella strains were further verified by AMOS-PCR. Cluster analyze on six Brucella strains were performed with Bio-Numerics 5.0 software and for examining and revealing the genetic characteristics of the related strains. Results During 2004-2018, a total of 16 704 HB cases were reported, with the incidence rate as 35.41/100 000. The incidence rates appeared as 110.51/100 000 in Jarud Banner and 67.84/100 000 in Kulun flag, which were both higher than the other areas. Most of the cases were reported in the 40-54 year olds, which accounted for 48.75% (8 143/16 704). The number of HB in farmers appeared as 14 873, which counted for 89.04% (14 873/16 704) of all the cases. Male to female ratio of incidence was 2.40:1. Most of the reported cases appeared between March to May, which accounted for 56.30% (9 405/16 704). Peak of the disease was seen in April. Using the conventional identification method, results showed that the available six strains all belonged to B. melitensis, including three of them as B. melitensis bv.1 and others three strains as B. melitensis bv. 3. Results from the amplified AMOS-PCR showed that all the strains were B. melitensis. The six strains clustered in two MLVA-11 genotypes (111 and 116) and all belonged to the Eastern Mediterranean lineage. Based on the MLVA-16 cluster analysis, results suggested that strains from this study were having close genetic relationship with B. melitensis strains that were from Jilin and Heilongjiang provinces. Conclusions Human brucellosis identified in Tongliao area was with greater risk in spreading the disease to the vicinity. Our findings indicated that the programs on detection and control of the disease should be strengthened.
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