文章摘要
朱娟,马山蕊,李新庆,魏文强.中国食管癌患者生活质量研究系统综述[J].中华流行病学杂志,2020,41(9):1536-1541
中国食管癌患者生活质量研究系统综述
A systematic review on quality of life of esophageal cancer patients in China
收稿日期:2019-11-04  出版日期:2020-09-18
DOI:10.3760/cma.j.cn112338-20191104-00782
中文关键词: 食管肿瘤;生活质量;系统综述
英文关键词: Esophageal cancer;Quality of life;Systematic review
基金项目:国家重点研发计划精准医学研究(2016YFC0901400,2016YFC0901404)
作者单位E-mail
朱娟 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室, 北京 100021  
马山蕊 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室, 北京 100021  
李新庆 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室, 北京 100021  
魏文强 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室, 北京 100021 weiwq@cicams.ac.cn 
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中文摘要:
      目的 了解我国2009-2019年食管癌患者生活质量研究现状。方法 系统检索中国知网、万方数据知识服务平台、PubMed和EMbase数据库,摘录基本信息、概括涉及量表并汇总分析不同量表的评价结果。结果 最终纳入127项研究(中文121项,英文6项),79项发表于近5年,涉及全国26个省(自治区、直辖市),仅4项多中心研究,超过1/2(72项)研究样本量<150例。纳入研究主要集中在医疗护理领域(58项)和治疗方案或药物效果评价(40项)。共涉及6种特异性量表(最常用的为生活质量核心调查问卷QLQ-C30,共74项)、4种通用性量表(最常用的为健康相关生命质量量表SF-36,共17项)和自制生活质量调查问卷。几乎所有量表均关注躯体、生理和社会关系维度,但具体条目内容和数量不同。纳入研究食管癌生活质量指标均为维度得分或总分,仅2项研究转化健康效用值数据。结论 我国食管癌生活质量研究数量增长较快,以特异性量表QLQ-C30和通用性量表SF-36生活质量测量工具为代表,主要为食管癌医疗护理和治疗效果评价的小样本研究,食管癌健康效用值相关数据仍匮乏。
英文摘要:
      Objective To systematically review the quality of life of esophageal cancer patients in China. Methods Based on CNKI, Wanfang, PubMed and EMbase database, related articles published from January 2009 to August 2019 were systematically retrieved. We extracted the basic information, synthesized and summarized related instruments evaluation results. Results A total of 127 studies were included (121 in Chinese, 6 in English), involving 26 provinces, of which 79 studies were published in the past 5 years and only 4 studies were multicenter study. More than half of included studies had a sample size of <150 cases (72 studies). Most studies were from the medical care and nursing field (58 studies) and were about the evaluation and comparison of treatments and medicine (40 studies). Six specific tools, including most commonly used Core Quality of Life Questionnaire (QLQ-C30) reported in 74 studies, 4 generic instruments, including most commonly used 36-item Short Form Health Survey (SF-36) reported in 17 studies and several self-designed questionnaires, were used. All the instruments focused on physical, physiological and social dimensions, but the specific contents and numbers of items were different. The index of quality of life used were dimension scores and total scores, and only 2 studies were about the health-related utility of esophageal cancer patients. Conclusions In China, the research on the quality of life of esophageal cancer patients increased rapidly over the past decade, but most were single-center and small sample studies. The esophageal cancer-specific QLQ-C30 and generic SF-36 were the most commonly used instruments in the studies. The medical care and nursing and evaluation of treatments were the main concerns, but the research on health utility scores of esophageal cancer was still limited in China.
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