文章摘要
赵培祯,程伟彬,唐卫明,郑和平,杨斌,王成.通过HIV/梅毒联合自我检测促进男男性行为人群进行梅毒检测的效果研究[J].中华流行病学杂志,2021,42(2):273-277
通过HIV/梅毒联合自我检测促进男男性行为人群进行梅毒检测的效果研究
Evaluating the effectiveness of HIV/syphilis joint self-testing in promoting syphilis testing among men who have sex with men
收稿日期:2020-06-24  出版日期:2021-02-24
DOI:10.3760/cma.j.cn112338-20200624-00880
中文关键词: 男男性行为人群;梅毒;艾滋病病毒;自我检测
英文关键词: Men who have sex with men;Syphilis;HIV;Self-testing
基金项目:国家自然科学基金(81903371);国家重点研发计划(2017YFE0103800);国家科技重大专项(2018ZX10101-001-001-003);广东省医学科学技术研究基金(A2018508,A2019524)
作者单位E-mail
赵培祯 南方医科大学皮肤病医院, 广州 510095  
程伟彬 南方医科大学皮肤病医院, 广州 510095  
唐卫明 南方医科大学皮肤病医院, 广州 510095
美国北卡罗来纳大学教堂山分校中国项目办, 广州 510095 
 
郑和平 南方医科大学皮肤病医院, 广州 510095  
杨斌 南方医科大学皮肤病医院, 广州 510095  
王成 南方医科大学皮肤病医院, 广州 510095 wangcheng090705@gmail.com 
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中文摘要:
      目的 评估HIV/梅毒联合自我检测(自检)在促进MSM梅毒检测方面的作用。方法 2019年7月通过淡蓝网(https://www.danlan.org)招募研究对象,将符合纳入标准的研究对象按照1:1:1随机分为3组:HIV/梅毒联合自检组、彩票激励自检组和对照组。对HIV/梅毒联合自检组和彩票激励自检组通过网络邮寄HIV/梅毒联合自检试剂,对照组鼓励其到线下场所进行检测。1个月后随访研究对象,评估3个组梅毒检测比例的差别。结果 研究对象145人,其中对照组48人,HIV/梅毒联合自检组49人,彩票激励自检组48人。在随访期间HIV/梅毒联合自检组梅毒检测比例为74.4%(32/43),彩票激励自检组为70.0%(28/40),对照组为36.4%(16/44)。多因素logistic回归分析结果显示,HIV/梅毒联合自检组、彩票激励自检组在随访期间进行梅毒检测的比例分别是对照组的5.38(95%CI2.06~14.04)倍和4.54(95%CI:1.75~11.74)倍。结论 HIV/梅毒联合自检、彩票激励自检均可以提高MSM的梅毒检测比例。HIV/梅毒联合自检具有推广的可行性。
英文摘要:
      Objective To evaluate the effectiveness of HIV/syphilis joint self-testing in promoting syphilis testing among men who have sex with men (MSM).Methods In July 2019, the research participants were recruited through the Danlan website (https://www.danlan.org). Participants who met the selection criteria, and were randomly assigned into one of the three study groups (1:1:1) including HIV/syphilis joint self-testing group and lottery incentive self-testing group and control group. Self-test reagents were mailed to HIV/syphilis joint self-testing group and lottery incentive self-testing group, and the subjects in control group were encouraged to go to offline locations for testing. One month later, follow-up was conducted to evaluate the differences in the testing rates of syphilis among the three groups.Results A total of 145 subjects were included in this study, including 48 in control group, 49 in HIV/syphilis joint self-testing group and 48 in lottery incentive self-testing group. During the follow-up period, the self-testing rate of syphilis was 74.4% (32/43) in HIV/syphilis joint self-testing group, 70.0% (28/40) in lottery incentive self-testing group and 36.4% (16/44) in control group. Multivariate logistic analysis revealed that the proportions of syphilis testing in HIV/syphilis joint self-testing group and lottery incentive self-testing group were 5.38 (95%CI:2.06-14.04) times and 4.54 (95% CI:1.75-11.74) times higher than that in control group during the follow-up period.Conclusions HIV/syphilis joint self-testing and lottery-incentives-prompted self-testing significantly increased the testing rate of syphilis in MSM, respectively. HIV/syphilis joint self-testing is feasible for promotion.
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