文章摘要
宣岩,魏兰馨,洪翔,朱晓玥,董书衡,严沁宇,王亮红,王蓓.我国不同人群生殖支原体感染率的Meta分析[J].中华流行病学杂志,2021,42(2):335-342
我国不同人群生殖支原体感染率的Meta分析
A Meta-analysis on the infection rates on Mycoplasma genitalium in the genitourinary tract of different populations in China
收稿日期:2020-05-30  出版日期:2021-02-24
DOI:10.3760/cma.j.cn112338-20200530-00791
中文关键词: 生殖支原体;泌尿生殖道;Meta分析
英文关键词: Mycoplasma genitalium;Urogenital tract;Meta-analysis
基金项目:国家自然科学基金(81872634)
作者单位E-mail
宣岩 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
魏兰馨 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
洪翔 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
朱晓玥 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
董书衡 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
严沁宇 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
王亮红 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009  
王蓓 东南大学公共卫生学院流行病与卫生统计学系, 南京 210009 wangbeilxb@seu.edu.cn 
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中文摘要:
      目的 生殖支原体(Mg)主要通过性接触传播,近年来国内外学者对生殖支原体感染和致病给予了较多的关注。本文旨在全面了解生殖支原体在我国不同人群泌尿生殖道中的感染情况,为进一步研究其致病特性提供依据。方法 检索中国期刊全文数据库(CNKI)、万方数据知识服务平台、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science等文献库,检索时间从建立数据库至2020年3月10日,涉及我国人群Mg感染的横断面研究文献。由2名评价员根据纳入与排除标准分别独立筛选并评价文献,交叉核对,采用R 1.1.463软件,对我国不同人群泌尿生殖道生殖支原体感染率进行Meta分析。异质性检验中,若I2 ≤ 50%采用固定效应模型,若I2>50%采用随机效应模型,并通过亚组分析,分析异质性来源。结果 本文共纳入47篇研究文献,均为中高质量文献,且无明显发表偏倚,结果较为可信。研究文献涉及19个省(自治区、直辖市)、中国香港特别行政区,包括普通体检人群519例、医院STD门诊就诊患者10 504例、妇科就诊患者3 200例、泌尿外科就诊患者1 624例、MSM 1 082例、暗娼1 842例、HIV感染者3 691例。Meta分析显示,普通体检人群的Mg感染率为0.94%(95%CI:0.07%~2.78%)、医院STD门诊就诊患者的Mg感染率为11.58%(95%CI:8.57%~14.97%)、妇科就诊患者的Mg感染率为15.22%(95%CI:7.99%~24.27%)、泌尿外科就诊患者的Mg感染率为7.32%(95%CI:4.24%~11.16%)、MSM的Mg感染率为9.70%(95%CI:3.06%~19.52%)、暗娼的Mg感染率为13.49%(95%CI:11.97%~15.08%)、HIV感染者的Mg感染率为20.46%(95%CI:13.67%~28.22%)。结论 普通体检人群的Mg感染率较低,但其他人群泌尿生殖道Mg感染率较高,值得进一步关注。
英文摘要:
      Objective Mycoplasma genitalium (Mg) is an opportunity pathogenic microorganism mainly transmitted through sexual contact. In recent years, scholars have paid more attention to Mg infection and pathogenicity. This study was aimed to understand the condition of Mg in the genitourinary tract of different populations in China and provide evidence for further study of its pathogenic characteristics.Methods Cross-section studies of Mg infection in the Chinese community were searched by China National Knowledge Infrastructure (CNKI), Wanfang digital database, SinoMed, Pubmed, and Web of Science from database construction to March 10th, 2020. Studies were sifted and screened independently by two evaluators based on inclusion and exclusion criteria, and Meta-analysis was conducted with R 1.1.463. If I2 ≤ 50%, the fixed-effect model should be adopted, if I2>50%, the random effect model should be adopted, and through subgroup analysis, the source of heterogeneity should be found out as far as possible.Results A total of 47 research articles were included in this article, all of which were medium and high-quality articles. There was no obvious publication bias, and the results were more reliable. The research contained 19 provinces and Hong Kong Special administrative region, including 519 healthy people, 10 504 patients from clinics or hospitals of sexual transmitted disease (STD), 3 200 on Gynecology and 1 624 on Urology, 1 082 patients with men who have sex with men(MSM), 1 842 patients with Female sex worker(FSW), and 3 691 patients with HIV/AIDS. The infection rate of Mg in the genitourinary tract of the healthy population was 0.94% (95%CI:0.07%-2.78%), the infection rate of Mg was 11.58% (95%CI:8.57%-14.97%), 15.22% (95%CI:7.99%-24.27%), 7.32% (95%CI:4.24%-11.16%) among patients from clinics or hospitals of STD, gynecology and urology respectively. The infection rate of MSM was 9.70% (95%CI:3.06%-19.52%),the infection rate of FSW was 13.49% (95%CI:11.97%-15.08%). The infection rate of Mg among HIV infected patients was 20.46% (95%CI:13.67%-28.22%).Conclusions The infection rate of Mg in a healthy population was low. Mg infection rate in the genitourinary tract of other groups was still higher, which is worthy of further attention.
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