| 奚玉娥,高文静,吕筠,余灿清,王胜锋,黄涛,孙点剑一,廖春晓,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.基于中国双生子人群的冠心病遗传-BMI交互作用研究[J].中华流行病学杂志,2021,42(9):1573-1579 |
| 基于中国双生子人群的冠心病遗传-BMI交互作用研究 |
| Gene-body mass index interaction on coronary heart disease in Chinese adult twins |
| 收稿日期:2020-11-30 出版日期:2021-09-27 |
| DOI：10.3760/cma.j.cn112338-20201130-01362 |
| 中文关键词: 冠心病 体质指数 遗传-环境交互作用 双生子研究 |
| 英文关键词: Coronary heart disease Body mass index Gene-environment interaction Twin study |
| 基金项目:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81711530051） |
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| 中文摘要: |
| 目的 分析冠心病患病的遗传-BMI交互作用。方法 利用中国双生子登记系统募集的20 340对≥ 25岁的同性别双生子，构建单变量遗传-环境交互作用模型，通过评估BMI对冠心病遗传效应的修饰作用反映冠心病的遗传-BMI交互作用。结果 调整年龄后，在男性中发现BMI对冠心病患病受到的遗传效应有负向修饰作用，遗传效应修饰系数（βa）及95% CI为-0.14（-0.22~-0.04），说明log-BMI每增加1个标准差，冠心病的遗传通径系数减小0.14，从而导致冠心病的遗传效应减小。而且低BMI（<24.0 kg/m2）男性冠心病患病的遗传度为0.77（0.65~0.86），而高BMI（≥ 24.0 kg/m2）组对应模型中的遗传度为0.56（0.33~0.74）。在女性中未观察到冠心病的遗传-BMI交互作用。结论 中国成年男性双生子人群中发现冠心病患病的遗传-BMI交互作用，且遗传因素在低BMI组冠心病患病中发挥更重要的作用。 |
| 英文摘要: |
| Objective To explore the gene-body mass index (BMI) interaction on coronary heart disease (CHD) in the Chinese adult twins. Methods A total of 20 340 same-sex twin pairs registered in the Chinese National Twin Registry (CNTR) were enrolled in this study. Classical twin structure equation model was used to estimate the gene-BMI interaction on CHD. Results After adjusting for age, we found that genetic variance of CHD differed as the function of BMI in male twins, which indicated the presence of a gene-BMI interaction on CHD (P=0.008).The genetic moderating effect (βa) was -0.14 (95%CI:-0.22--0.04), indicating that for each logarithmic transformation value of BMI increase, genetic path parameters would decrease by 0.14, which would result in the decrease of genetic variance of CHD. And the heritability of CHD was 0.77 (95%CI:0.65-0.86) among the male twins with lower BMI (<24.0 kg/m2), but 0.56 (95%CI:0.33-0.74) among the male twins with high BMI (≥ 24.0 kg/m2). However, there was no evidence suggesting that BMI could moderate genetic variants of CHD in female. Conclusion We found a significant gene-BMI interaction on CHD in the Chinese male adult twins in China, and the heritability of CHD was higher among the twins whose BMI was <24.0 kg/m2. |
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