文章摘要
李荻菲,陈会超,金晓媚,戴洁,曾志君,杨敏,孙鹏艳,董莉娟,韩瑜,马艳玲,陈敏,宋志忠.云南省2020年1-6月新报告HIV/AIDS的HCV与梅毒螺旋体感染状况分析[J].中华流行病学杂志,2021,42(11):1983-1988
云南省2020年1-6月新报告HIV/AIDS的HCV与梅毒螺旋体感染状况分析
HCV and Treponema pallidum infection status in HIV/AIDS cases in Yunnan province, January-June, 2020
收稿日期:2021-05-17  出版日期:2021-11-20
DOI:10.3760/cma.j.cn112338-20210517-00406
中文关键词: 艾滋病病毒;丙型肝炎病毒;梅毒螺旋体;合并感染
英文关键词: HIV;HCV;Treponema pallidum;Co-infection
基金项目:
作者单位E-mail
李荻菲 昆明医科大学公共卫生学院 650500  
陈会超 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
金晓媚 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
戴洁 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
曾志君 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
杨敏 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
孙鹏艳 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
董莉娟 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
韩瑜 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
马艳玲 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
陈敏 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022  
宋志忠 云南省疾病预防控制中心性病艾滋病防治所, 昆明 650022 song1208@126.com 
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中文摘要:
      目的 分析云南省HIV/AIDS的HCV与梅毒螺旋体(TP)的感染状况及其相关因素,为防控HIV/AIDS的HCV与TP合并感染提供参考依据。方法 采用横断面调查方法,选取2020年1月1日至6月30日云南省新报告HIV/AIDS作为研究对象。采用两种不同ELISA试剂检测血清HCV抗体,均阳性判定为HCV感染;采用ELISA法和甲苯胺红不加热血清试验检测TP,均阳性判定为TP感染;采用Excel 2016和SPSS 22.0软件进行数据整理和统计学分析,采用单因素和多因素logistic回归分析HCV及TP感染的相关因素。结果 5 922例HIV/AIDS中,HCV感染率为6.5%(383/5 922),TP感染率为5.8%(344/5 922),HCV和TP合并感染率为0.4%(22/5 922)。多因素logistic回归分析结果显示,相比于≥ 50岁组、女性、离异/丧偶、汉族和大专及以上文化程度、报告地为滇东地区、男男性传播途径,较低年龄组(15~岁:aOR=3.53;20~岁:aOR=3.02;30~岁:aOR=2.91;40~49岁:aOR=3.61)、男性(aOR=2.31)、已婚/未婚(已婚:aOR=1.61;未婚:aOR=1.63);少数民族(aOR=1.70)、较低文化程度(小学及以下:aOR=4.69;初中或高中:aOR=3.96)、报告地为滇中或滇西地区(滇中:aOR=2.46;滇西:aOR=7.08)、注射吸毒传播途径(aOR=131.08) HIV/AIDS的HCV感染风险较高。相比于初中或高中文化程度、农民职业、报告地区为滇西地区和异性性传播途径,小学及以下或大专及以上文化程度(小学及以下:aOR=1.73;大专及以上:aOR=1.77)、其他职业(aOR=1.39)、报告地为滇东地区(aOR=1.75)、男男性传播途径(aOR=9.75) HIV/AIDS的TP感染风险较高。结论 云南省2020年1-6月新报告HIV/AIDS中存在一定比例HCV与TP合并感染,合并感染的相关因素较多,应加强HIV/AIDS的HCV与TP血清学检测,开展HCV与TP合并感染的治疗。
英文摘要:
      Objective To understand the infection status of HCV and Treponema pallidum (TP) in HIV/AIDS cases in Yunnan province,and identify the risk factors. Methods Between January 1 and June 30 in 2020,a cross-sectional survey was conducted in Yunnan. Two enzyme-linked immunosorbent assay (ELISA) kits were used to detect anti-HCV, the positive results of both two kits indicated HCV infection. ELISA and syphilis toluidine red untreated serum test were applied to identify TP infection. Both Excel 2016 and SPSS 22.0 software were used for statistical analysis, and logistic regression model was conducted to identify the relevant factors of HCV and TP infection. Results A total of 5 922 HIV/AIDS cases were included in this study, the infection rates of HCV and TP were 6.5% (383/5 922) and 5.8% (344/5 922) respectively. The co-infection rate of HCV and TP was 0.4% (22/5 922). The risk for HCV infection in HIV/AIDS cases was higher in younger age groups compared with age group ≥ 50 years (15-19:aOR=3.53;20-29:aOR=3.02;30-39:aOR=2.91;40-49:aOR=3.61), in males than in females (aOR=2.31), in the married and unmarried than in the divorced or widowed (married:aOR=1.61;unmarried:aOR=1.63), in other ethnic groups than in Han ethnic group (aOR=1.70), in people with lower education level than in people with education level of college and above (primary school degree and below:aOR=4.69;middle school:aOR=3.96), in people living in the central and western Yunnan than in people living in eastern Yunnan (central Yunnan:aOR=2.46; western Yunnan:aOR=7.08), in injection drug users than in MSM (aOR=131.08). The risk of TP infection in HIV/AIDS cases was higher in people with education level of college and primary school than in middle school degree (primary school and below:aOR=1.73;college and above:aOR=1.77), in people with other occupations than in farmers (aOR=1.39), in people living in eastern Yunnan than in people living in western Yunnan (aOR=1.75); in MSM than in people with heterosex (aOR=9.75). Conclusions A certain proportion of HIV/AIDS cases reported between January and June in 2020 in Yunnan were co-infected with HCV and TP, many factors were associated with the co-infection. It is suggested to strengthen HCV and TP tests in HIV/AIDS cases and conduct active treatment of the co-infection.
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