文章摘要
李茂婷,张梦妮,职心乐,朱红,张欣,谢娟.双生子体质指数遗传度的Meta分析[J].中华流行病学杂志,2021,42(12):2188-2195
双生子体质指数遗传度的Meta分析
Heritability of body mass index based on twin studies: a Meta-analysis
收稿日期:2021-03-10  出版日期:2021-12-16
DOI:10.3760/cma.j.cn112338-20210310-00193
中文关键词: 体质指数;遗传度;双生子;Meta分析
英文关键词: Body mass index;Heritability;Twins;Meta-analysis
基金项目:国家自然科学基金(81602922);天津医科大学教育教学研究项目(2019ZJ002)
作者单位E-mail
李茂婷 天津医科大学公共卫生学院 300070  
张梦妮 天津医科大学公共卫生学院 300070  
职心乐 天津医科大学公共卫生学院 300070
天津市环境营养与人群健康重点实验室 300070
环境营养与人群健康国际联合研究中心, 天津 300070 
 
朱红 天津医科大学公共卫生学院 300070
天津市环境营养与人群健康重点实验室 300070
环境营养与人群健康国际联合研究中心, 天津 300070 
 
张欣 天津医科大学公共卫生学院 300070
天津市环境营养与人群健康重点实验室 300070
环境营养与人群健康国际联合研究中心, 天津 300070 
 
谢娟 天津医科大学公共卫生学院 300070
天津市环境营养与人群健康重点实验室 300070
环境营养与人群健康国际联合研究中心, 天津 300070 
xiejuan@tmu.edu.cn 
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中文摘要:
      目的 采用Meta分析方法,了解双生子BMI遗传度。方法 通过检索中国知网、万方数据知识服务平台、维普数据库、PubMed和Web of Science数据库,获得截至2020年12月31日双生子BMI遗传度的研究。采用现况调查偏倚风险评价标准评价纳入文献的质量。采用Stata 16.0软件对结局指标(遗传度,95%CI)进行亚组分析,探索异质性来源和局部加权回归法拟合遗传度随年龄的变化趋势,并对纳入的文献进行发表偏倚检验和敏感性分析。结果 共纳入符合纳入排除标准的文献10篇,共纳入79个双生子BMI遗传度独立估计值。Meta分析显示,BMI遗传度合并值为0.69(95%CI:0.65~0.71),男性合并值(0.68,95%CI:0.65~0.70)低于女性合并值(0.70,95%CI:0.68~0.72);儿童青少年时期的BMI遗传度(0.72,95%CI:0.68~0.76)比成年时高(0.68,95%CI:0.66~0.70);≤ 18岁的双生子BMI遗传度性别间的差异更大,男性(0.68,95%CI:0.61~0.76)低于女性(0.75,95%CI:0.69~0.81)。遗传度随年龄的变化趋势:儿童时期随年龄的增长而上升,至18岁左右达到峰值,其后随年龄的增加缓慢下降。结论 BMI遗传度受人口特征影响,特别是年龄和性别。鉴于女性青少年时期BMI遗传度估计值较高,应给予更多关注,把握健康干预的切入点。
英文摘要:
      Objective To use Meta analysis to understand the prevalence of the heritability of body mass index (BMI) in twins. Methods All studies on the heritability of the twins' BMI published before December 31, 2020 were retrieved through the China National Knowledge Network, Wanfang, VIP, PubMed and Web of Science databases. The literature quality was evaluated by using Joanna Briggs Institute Critical Appraisal tools. Stata 16.0 was used to perform subgroup analysis on the outcome indicators (heritability, 95%CI) to explore the source of heterogeneity. The local weighted regression method was used to fit the trend of heritability with age. The publication bias test and the sensitivity analysis of included literatures were also performed by using Stata 16.0.Results A total of 10 articles meeting the inclusion and exclusion criteria were included with 79 twins' independent estimates of heritability for BMI. Meta-analysis showed that the combined value of BMI heritability was 0.69 (95%CI:0.65-0.71), the combined value of BMI (0.68, 95%CI:0.65-0.70) in males was lower than that (0.70, 95%CI:0.68-0.72) in females. The heritability of BMI (0.72, 95%CI:0.68-0.76) in childhood and adolescence was higher than that (0.68, 95%CI:0.66-0.70) in adulthood. The gender specific difference in BMI heritability in twins ≤ 18 years old was even greater, which was lower in males (0.68, 95%CI:0.61-0.76) than in females (0.75, 95%CI:0.69-0.81). The heritability increased with age in childhood, reached peak at about 18 years old, and then slowly decreased with age. Conclusions The heritability of BMI varied with population characteristics, especially age and gender. In view of the high estimated value of BMI heritability in female children and adolescents, more attention should be paid to the start time of health intervention.
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