文章摘要
王文秀,黄宁浩,吕筠,余灿清,郭彧,裴培,杜怀东,陈君石,陈铮鸣,黄涛,李立明,代表中国慢性病前瞻性研究项目协作组.中国儿童肥胖的遗传易感性与成年期缺血性心脏病发病风险的研究[J].中华流行病学杂志,2022,43(4):445-451
中国儿童肥胖的遗传易感性与成年期缺血性心脏病发病风险的研究
Association between genetic predisposition to childhood obesity and the risk of adult ischemic heart disease in China
收稿日期:2021-04-13  出版日期:2022-04-16
DOI:10.3760/cma.j.cn112338-20210413-00309
中文关键词: 儿童肥胖|缺血性心脏病|遗传易感性
英文关键词: Childhood obesity|Ischemic heart disease|Genetic predisposition
基金项目:国家重点研发计划(2020YFC2003401,2016YFC0900500,2016YFC0900501,2016YFC0900504);国家自然科学基金(81941018,91846303,91843302);中国香港Kadoorie Charitable基金
作者单位E-mail
王文秀 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191  
黄宁浩 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191  
吕筠 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
北京大学公众健康与重大疫情防控战略研究中心, 北京 100191
分子心血管学教育部重点实验室, 北京 100191 
 
余灿清 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
北京大学公众健康与重大疫情防控战略研究中心, 北京 100191 
 
郭彧 中国医学科学院阜外医院, 国家心血管病中心, 北京 100037  
裴培 中国医学科学院, 北京 100730  
杜怀东 英国牛津大学医学研究委员会人口健康研究组/临床与流行病学研究中心纳菲尔德人群健康系 OX3 7LF  
陈君石 国家食品安全风险评估中心, 北京 100022  
陈铮鸣 英国牛津大学医学研究委员会人口健康研究组/临床与流行病学研究中心纳菲尔德人群健康系 OX3 7LF  
黄涛 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191 huang.tao@pku.edu.cn 
李立明 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191
北京大学公众健康与重大疫情防控战略研究中心, 北京 100191 
 
代表中国慢性病前瞻性研究项目协作组   
摘要点击次数: 944
全文下载次数: 268
中文摘要:
      目的 分析儿童肥胖的测量学指标BMI相关基因序列变异与发生缺血性心脏病(IHD)、急性冠心病事件(MCE)的关联。方法 利用中国慢性病前瞻性研究中6.9万余名具有全基因组遗传数据的样本,剔除基线时患有冠心病、脑卒中、恶性肿瘤的个体,最终纳入64 454人。采用既往全基因组关联研究显著性遗传位点构建儿童BMI遗传风险评分,并根据其五分位数进行分组,最低五分位组为低遗传风险组,最高五分位组为高遗传风险组。采用Cox比例风险回归模型计算儿童BMI的遗传风险评分与IHD、MCE发生风险的关联。结果 研究对象平均随访10.7年,期间新发IHD 7 073例,MCE 1 845例。调整了性别、年龄、地区及前10个遗传主成分后,与低遗传风险组相比,高遗传风险组发生IHD、MCE的HRs值(95%CIs)分别为1.10(1.02~1.18)、1.10(0.95~1.27)。遗传风险评分每增加一个标准差,IHD的发病风险增加4%(2%~6%)(线性趋势P=0.001)。进一步调整基线BMI后,高遗传风险组与低遗传风险组的效应值差异无统计学意义,但遗传风险评分与IHD发病风险间仍具有线性趋势(P=0.019)。结论 成年人IHD风险随儿童肥胖遗传易感性的增加而增加,提示儿童肥胖是发生IHD的危险因素。儿童肥胖作为一个容易识别的特征,应定期关注其变化情况,实现成年人IHD的早期干预。
英文摘要:
      Objective To examine the associations of childhood obesity, assessed by genetic variations of childhood body mass index (BMI), with the risk of adult ischemic heart disease (IHD) and major coronary event (MCE). Methods More than 69 000 participants from the China Kadoorie Biobank were genotyped. After excluding those with coronary heart disease, stroke, or cancer at baseline, a total of 64 454 participants were included in this study. Based on genome-wide significant single nucleotide polymorphisms (SNPs), childhood BMI genetic risk score were constructed for every participant and divided into quintiles, with the lowest quintile as the low genetic risk group and the highest quintile as the high genetic risk group. Cox proportional hazards regression models were used to estimate the association between genetic predisposition to childhood obesity and the risk of ischemic heart disease. Results During a median of 10.7 years of follow-up, 7 073 incident cases of IHD and 1 845 cases of MCE were documented. After adjusting for sex, age, region, and the first ten genetic principal components, the HRs (95%CIs) for IHD and MCE in the high genetic risk group were 1.10 (1.02-1.18) and 1.10 (0.95-1.27), compared with the low genetic risk group. IHD risk increased by 4% (2%-6%) for each one standard deviation increase in genetic risk score (trend P=0.001). After further adjustment for baseline BMI, the differences between genetic risk groups were not statistically significant, but there was still a linear trend between genetic risk score and IHD risk (trend P=0.019). Conclusions IHD risk increased with genetic predisposition to childhood obesity, suggesting that childhood obesity is an important risk factor for the development of IHD in China. As an easily identifiable feature, changes of childhood BMI should be monitored regularly to realize early intervention of IHD in adults.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭