文章摘要
伊娜,刘婷婷,周宇畅,齐金蕾,申昆玲,周脉耕.1990-2019年中国儿童青少年哮喘疾病负担分析[J].中华流行病学杂志,2023,44(2):235-242
1990-2019年中国儿童青少年哮喘疾病负担分析
Disease burden of asthma among children and adolescents in China, 1990-2019
收稿日期:2022-06-02  出版日期:2023-02-15
DOI:10.3760/cma.j.cn112338-20220526-00469
中文关键词: 哮喘  儿童  青少年  疾病负担
英文关键词: Asthma  Children  Adolescents  Burden of disease
基金项目:首都卫生发展科研专项(2022-1G-4241)
作者单位E-mail
伊娜 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050
中国医科大学公共卫生学院, 沈阳 110122 
 
刘婷婷 国家儿童医学中心/首都医科大学附属北京儿童医院呼吸科/国家呼吸系统疾病临床医学研究中心, 北京 100045  
周宇畅 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
齐金蕾 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050  
申昆玲 国家儿童医学中心/首都医科大学附属北京儿童医院呼吸科/国家呼吸系统疾病临床医学研究中心, 北京 100045 kunlingshen1717@163.com 
周脉耕 中国疾病预防控制中心慢性非传染性疾病预防控制中心, 北京 100050 zhoumaigeng@ncncd.chinacdc.cn 
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中文摘要:
      目的 分析1990-2019年我国1~19岁儿童青少年哮喘疾病负担及其变化趋势,为优化儿童青少年哮喘的健康管理提供依据。方法 利用2019年全球疾病负担中国分省研究结果,比较1990年和2019年中国儿童青少年哮喘的发病、患病、死亡和伤残调整寿命年(DALY),描述1990-2019年我国各省份儿童青少年哮喘疾病负担的分布情况。结果 2019年我国儿童青少年哮喘发病人数、患病人数和死亡人数分别为215.41万[95%不确定区间(UI):137.80万~319.76万]、869.07万(95%UI:579.83万~1 312.65万)和78(95%UI:63~106),发病率、患病率和死亡率分别为718.23/10万(95%UI:459.47/10万~1 066.17/10万)、2 897.73/10万(95%UI:1 933.33/10万~4 376.75/10万)和0.03/10万(95%UI:0.02/10万~0.04/10万)。相较于1990年,2019年儿童青少年哮喘发病率和患病率均上升[变化率为3.28%(95%UI:-0.66%~7.27%)和0.58%(95%UI:-3.33%~4.18%)],死亡率下降[变化率为-92.17%(95%UI:-94.97%~-85.78%)]。1990-2019年我国儿童青少年哮喘的年龄标化DALY率下降了17.91%,整体上看,降幅呈现东部地区小、西部地区大的趋势。降幅较大的省份为云南省(-53.15%)、贵州省(-45.46%)和西藏自治区(-35.61%)。香港特别行政区(0.65%)是唯一出现了疾病负担增加的地区。2019年我国各省份的儿童青少年哮喘年龄标化DALY率在103.26人年/10万~144.35人年/10万之间。年龄标化DALY率最高的为香港特别行政区,最低的为黑龙江省。男性儿童青少年哮喘的疾病负担高于女性。结论 1990-2019年中国儿童青少年哮喘的发病率和患病率上升,死亡率下降。年龄标化DALY率也有所下降,但降幅存在地区差异。男性的疾病负担大于女性。应继续开展儿童青少年哮喘的相关研究和防治工作。
英文摘要:
      Objective To analyze the burden of asthma disease and its trends among children and adolescents aged 1 to 19 years in China during 1990-2019 and to provide a basis for optimizing the health management strategy of asthma in children and adolescents. Methods Data based on the 2019 Global Burden of Disease Study for China were used to compare the incidence, prevalence, death, and disability adjusted life year (DALY) of children and adolescents with asthma in 1990 and 2019 and to describe the distribution of the disease burden of asthma in children and adolescents by provincial administrative regions in China from 1990 to 2019. Results In 2019, the number of incidence, prevalence, and death were 2 154 100[95% uncertainty interval (UI):1 378 000-3 197 600], 8 690 700 (95%UI:5 798 300-13 126 500), and 78 (95%UI:63-106), respectively. The incidence, prevalence, and mortality were 718.23/100 000 (95%UI:459.47/100 000-1 066.17/100 000), 2 897.73/100 000 (95%UI:1 933.33/100 000-4 376.75/100 000), and 0.03/100 000 (95%UI:0.02/100 000-0.04/100 000), respectively. The incidence and prevalence increased[change rate:3.28% (95%UI:-0.66%-7.27%) and 0.58% (95%UI:-3.33%-4.18%)], respectively, and the mortality decreased[change rate:-92.17% (95%UI:-94.97%- -85.78%)] compared with 1990. The age-standardized DALY rate decreased by 17.91% from 1990 to 2019. On the whole, the rate of decline showed less in the eastern and more in the western areas. The three provinces with the most significant decreases were Yunnan Province (-53.15%), Guizhou Province (-45.46%), and Tibet Autonomous Region (-35.61%). Hong Kong Special Administrative Region (0.65%) was the only region showing an increase in disease burden. The age-standardized DALY rate for asthma in children and adolescents ranged from 103.26/100 000 to 144.35/100 000 by the province in 2019. The province with the highest age-standardized DALY rate was Hong Kong Special Administrative Region (144.35/100 000), and the lowest was Heilongjiang Province (103.26/100 000). The asthma disease burden was higher in male children and adolescents than in females. Conclusions Incidence and prevalence of asthma increased, and mortality decreased in children and adolescents in China from 1990-2019. The age-standardized DALY rate also decreased, but there were regional disparities in the rate of decline. The disease burden was more significant in males than in females. Research and prevention efforts for asthma in children and adolescents should be continued.
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