文章摘要
程雁鹏,孔东锋,张佳,吕子全,陈志高,熊华威,路滟,罗青山,吕秋莹,赵锦,温莹,万佳,陆芳芳,逯建华,邹旋,张振.深圳市一起新型冠状病毒Omicron BF.7变异株暴发疫情的流行病学特征[J].中华流行病学杂志,2023,44(3):379-385
深圳市一起新型冠状病毒Omicron BF.7变异株暴发疫情的流行病学特征
Epidemiological characteristics of a 2019-nCoV outbreak caused by Omicron variant BF.7 in Shenzhen
收稿日期:2022-10-31  出版日期:2023-03-14
DOI:10.3760/cma.j.cn112338-20221031-00926
中文关键词: 新型冠状病毒感染  新型冠状病毒  Omicron变异株  流行病学特征  传播链
英文关键词: COVID-19  2019-nCoV  Omicron variant  Epidemiological characteristics  Transmission chain
基金项目:深圳市医学重点学科(SZXK064);深圳市医疗卫生三名工程项目(SZSM202011008)
作者单位E-mail
程雁鹏 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
孔东锋 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
张佳 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
吕子全 深圳市疾病预防控制中心中心实验室, 深圳 518055  
陈志高 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
熊华威 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
路滟 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
罗青山 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
吕秋莹 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
赵锦 深圳市疾病预防控制中心艾滋病预防控制所, 深圳 518055  
温莹 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
万佳 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055  
陆芳芳 深圳市宝安区公共卫生福永分中心, 深圳 518103  
逯建华 深圳市疾病预防控制中心办公室, 深圳 518055  
邹旋 深圳市疾病预防控制中心办公室, 深圳 518055 914494557@qq.com 
张振 深圳市疾病预防控制中心传染病预防控制所, 深圳 518055 47176976@qq.com 
摘要点击次数: 874
全文下载次数: 143
中文摘要:
      目的 分析深圳市一起广东省外输入的新型冠状病毒(新冠病毒)Omicron BF.7变异株所致暴发疫情的流行病学特征,梳理和分析其传播链条和传播特征。方法 采用现场流行病学方法对病例进行调查,整理新冠病毒感染者活动轨迹、分析代际关系等,对新冠病毒核酸阳性标本进行基因测序分析。结果 2022年10月8-23日,深圳市共报告196例新冠病毒感染者,均存在流行病学关联。男、女性分别为100和96例,年龄MQ1Q3)为33(25,46)岁。本起疫情由在广东省外旅游返回深圳市的新冠病毒感染者(首发病例)引起,4条传播链分别为首发病例现住址相关感染8例、7日晚社会面活动相关感染65例、8日写字楼工作场所相关感染累计48例、在工作场所附近的写字楼相关感染74例。本起疫情潜伏期MQ1Q3)为1.44(1.11,2.17)d。室内暴露的潜伏期短于室外暴露的潜伏期,MQ1Q3)分别为1.38(1.06,1.84)和1.95(1.22,2.99)d,差异有统计学意义(Wald χ2=10.27,P=0.001)。随着代际的增加,基因位点突变个数及突变比例增加。在同一传播链疫情时,传播1代的新增基因突变位点1~3个的占比较高。结论 本起疫情传播链清晰,新冠病毒Omicron BF.7变异株的潜伏期短,传播速度快,基因突变比例较高。在疫情处置时,应加快疫情处置速度,严格落实防控政策。
英文摘要:
      Objective To explore the epidemiological characteristic of a COVID-19 outbreak caused by 2019-nCoV Omicron variant BF.7 and other provinces imported in Shenzhen and analyze transmission chains and characteristics. Methods Field epidemiological survey was conducted to identify the transmission chain, analyze the generation relationship among the cases. The 2019-nCoV nucleic acid positive samples were used for gene sequencing. Results From 8 to 23 October, 2022, a total of 196 cases of COVID-19 were reported in Shenzhen, all the cases had epidemiological links. In the cases, 100 were men and 96 were women, with a median of age, M (Q1, Q3) was 33(25, 46) years. The outbreak was caused by traverlers initial cases infected with 2019-nCoV who returned to Shenzhen after traveling outside of Guangdong Province.There were four transmission chains, including the transmission in place of residence and neighbourhood, affecting 8 persons, transmission in social activity in the evening on 7 October, affecting 65 persons, transmission in work place on 8 October, affecting 48 persons, and transmission in a building near the work place, affecting 74 persons. The median of the incubation period of the infection, M (Q1, Q3) was 1.44 (1.11, 2.17) days. The incubation period of indoor exposure less than that of the outdoor exposure, M (Q1, Q3) was 1.38 (1.06, 1.84) and 1.95 (1.22, 2.99) days, respcetively (Wald χ2=10.27, P=0.001). With the increase of case generation, the number and probability of gene mutation increased. In the same transmission chain, the proportion of having 1-3 mutation sites was high in the cases in the first generation. Conclusions The transmission chains were clear in this epidemic. The incubation period of Omicron variant BF.7 infection was shorter, the transmission speed was faster, and the gene mutation rate was higher. It is necessary to conduct prompt response and strict disease control when epidemic occurs.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭