| 刘博蕊,胡嘉晋,万宁钰,于洋,刘洋,马亚楠,闻德亮.基于基因与环境交互作用的儿童肥胖病因研究进展[J].中华流行病学杂志,2023,44(3):511-515 |
| 基于基因与环境交互作用的儿童肥胖病因研究进展 |
| Progress in research of etiology of childhood obesity based on interaction between genes and environment |
| 收稿日期:2022-05-07 出版日期:2023-03-14 |
| DOI：10.3760/cma.j.cn112338-20220507-00390 |
| 中文关键词: 儿童肥胖 基因与环境交互作用 宫内暴露 膳食 体力活动 表观遗传 |
| 英文关键词: Childhood obesity Interaction between genes and environment Intrauterine exposure Diet Physical activity Epigenetic |
| 基金项目:国家自然科学基金（82103860）；辽宁省博士科研启动基金（2020-BS-114） |
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| 中文摘要: |
| 儿童肥胖是全球性的公共健康问题，不仅危害儿童自身健康，还是成年期慢性病发病的重要诱因。近年来，随着精准医学研究的深入开展，越来越多的研究证据指明环境、行为因素，如早期宫内环境、儿童饮食、体力活动等，与儿童自身基因风险对肥胖的发病具有显著的交互作用，可以促进或抑制儿童肥胖的发生发展。本文对该领域现有研究进行综述，总结基因风险和环境暴露因素对儿童肥胖发病的交互作用及潜在机制，为不同遗传背景儿童的肥胖精准防控提供参考依据。 |
| 英文摘要: |
| Childhood obesity is a global public health problem, which can not only endangers children's health, but also might be an important cause of chronic diseases in adulthood. In recent years, with the in-depth development of precision medicine research, more and more research evidences have shown that there are interactions between environmental factors, such as early intrauterine environment, children's diet, physical activity and children's gene factor on the incidence of childhood obesity, which can result in or inhibit the incidence and development of childhood obesity. This paper summarizes the progress in research in this field to reveal the effects and potential mechanisms of genetic factors and environmental factors on the incidence of childhood obesity in order to provide reference for the precise prevention and control of childhood obesity under different genetic backgrounds. |
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