| 钟活麟,赵和平,李凌华,李全敏,罗丹,邹华春.抗病毒治疗后不同免疫重建水平HIV感染者基线生化指标及艾滋病直接相关合并症差异[J].中华流行病学杂志,2023,44(8):1283-1289 |
| 抗病毒治疗后不同免疫重建水平HIV感染者基线生化指标及艾滋病直接相关合并症差异 |
| Differences in biochemical indexes and AIDS-related complications at baseline in HIV- infected patients with different levels of immune reconstitution after antiretroviral therapy |
| 收稿日期:2023-01-13 出版日期:2023-08-18 |
| DOI：10.3760/cma.j.cn112338-20230113-00027 |
| 中文关键词: 艾滋病病毒 抗病毒治疗 免疫重建 生化指标 合并症 |
| 英文关键词: HIV Antiretroviral therapy Immune reconstitution Biochemical index Complication |
| 基金项目:国家自然科学基金（82022064） |
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| 中文摘要: |
| 目的 了解抗病毒治疗(ART)后不同免疫重建水平HIV感染者的基线生化指标及艾滋病直接相关合并症差异。方法 以2010年1月至2017年12月广州医科大学附属市八医院感染门诊随访超过24个月成年初治HIV感染者为研究对象。根据基线CD4+ T淋巴细胞计数<200、200~350和>350个/µl的不同水平分为免疫重建不良组、部分免疫重建组和免疫重建良好组。采用Kruskal-Wallis H和χ²检验分析不同组的基线社会人口学特征、生化指标及艾滋病直接相关合并症的差异。采用SPSS 20.0软件进行统计学分析。结果 共纳入研究对象3 900例,免疫重建不良组、部分免疫重建组和免疫重建良好组分别为385例(9.9%)、1 206例(30.9%)和2 309例(59.2%)。免疫重建不良组的基线白细胞、血小板、血红蛋白、TG、TC、FPG、AST、ALT及总胆红素等生化指标与免疫重建良好组差异有统计学意义(均P<0.05)。免疫重建不良组的基线合并肺结核、耶氏肺孢子菌肺炎、播散性真菌病、食管念珠菌病、肺外结核、皮炎、口腔念珠菌感染、口腔黏膜毛状白斑、持续腹泻 ≥ 1个月及持续或间断发热 ≥ 1个月等艾滋病直接相关合并症的占比明显高于免疫重建良好组,差异有统计学意义(均P<0.05)。结论 ART后获得不同免疫重建水平的HIV感染者基线生化指标和艾滋病直接相关合并症存在明显差异,需加强基线异常生化指标的监测和合并症的诊治。 |
| 英文摘要: |
| Objective To observe the differences in biochemical indexes and AIDS-related complications at baseline in HIV-infected patients with different levels of immune reconstitution to antiretroviral therapy (ART). Methods The subjects were treat-naïve adult HIV-infected patients who were followed up for more than 24 months in the Guangzhou Eighth People's Hospital affiliated infection clinic at Guangzhou Medical University from January 2010 to December 2017. CD4+ T lymphocyte count at baseline at <200, 200-350, and >350 cells/µl levels were divided into poor, partial, and good immune reconstitution groups. The Kruskal-Wallis H and chi-square tests were used to analyze the differences in baseline sociodemographic characteristics, biochemical indexes, and AIDS-related complications among different groups. The SPSS 20.0 software was used for statistical analysis. Results Among the 3 900 HIV-infected individuals, 385 cases (9.9%), 1 206 cases (30.9%), and 2 309 cases (59.2%) were grouped into poor, partial and good immune reconstitution groups, respectively. The baseline biochemical indexes of leukocyte, platelet, hemoglobin, TG, TC, FPG, AST, ALT and total bilirubin in the poor immune reconstitution group were significantly different from those in the good immune reconstitution group (all P<0.05). The proportion of AIDS-related complications at baseline in the poor immune reconstitution group, such as tuberculosis, pneumocystis yeli pneumonia, disseminated mycosis, esophageal candidiasis, extrapulmonary tuberculosis, dermatitis, oral candidiasis, oral mucous leukoplakia, continuous diarrhea for more than 1 month and continuous or intermittent fever for more than 1 month, was significantly higher than that in the good immune reconstitution group (all P<0.05). Conclusions The biochemical indexes and AIDS-related complications in HIV-infected patients with different levels of immune reconstitution were significantly different at baseline. Attention should be paid to monitoring abnormal biomedical indicators and AIDS-related complications at baseline. |
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