| 徐福根,钟银德,傅强,黄志诚,闻洪根,黄诚孝,吴静芳,姚怀芳,谢金康.麻疹感染的血凝抑制抗体临界滴度[J].Chinese journal of Epidemiology,1983,4(2):83-88 |
| 麻疹感染的血凝抑制抗体临界滴度 |
| The Critical Titre of Hemagglutination Inhibiting (HAI) Antibody in Measles Infection |
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| Abstract: |
| 1977~1980年在浙江省淳安、富阳、余杭县等7个麻疹流行公社中选择正在流行麻疹的生产队或自然村作为观察点,探索感染抗体的临界滴度。以生后8个月~15岁尚无麻疹史但有接触史的儿童548人作为观察对象,采双份血(麻疹流行前或流行高峰期和流行后一个月左右)以微量法测麻疹血凝抑制(HAI)有抗体。结果表明,HAI抗体滴度≤1:8的接触者都发生麻滴疹的可能。绝大多数麻疹病人感染时的抗体滴度<2。但度<2的接触者,未接种麻苗组发病率高于接种组。这可认为如疫苗免疫成功后HAI抗体降至测不出时并不一定都表示缺乏免疫力。 |
| English Abstract: |
| The critical titre of HAI antibody in measles infection was investigated in 1977—1980 in production brigades of seven people’s communes of Chunan, Fuyan, Yuhang counties. Zhejiang province, where measles was prevailing. The survey was carried out on 548 children, aged 8 months-15 years who had been exposed to measles with no history of infection. Double blood samples were collected before or at the peak of, and a month after the epidemic from the children and tested for HAI antibody.It was found that the close contacts with antibody titre ≤1:8 were accessible to the disease. The titre of most of infected children was < 2. However, among the contacts with a titre < 2, the morbidity of unvaccinated children was higher than that of vaccinated. It suggested that vaccination provided some protection even though the HAI antibody had disappeared. |
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