| 张作儒,孟宗达,伦继宗,解宝光,王明义,么振海,刘金声,尹伊居,谭保存,张春田,牛建章,纪通讯,李德祥,高惠敏,庞伯庄,尹文明.河北省有肾综合征出血热血清流行病学调查初步报告[J].Chinese journal of Epidemiology,1983,4(6):339-341 |
| 河北省有肾综合征出血热血清流行病学调查初步报告 |
| Preliminary Study on Serological Epidemiology of Epidemic Hemorrhagic Fever with Renal Syndrom |
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| Abstract: |
| 1980年11月以来,河北省报告8例有肾综合征出血热(HFRS),用间接免疫荧光(IFA)法和IFA抑制法对有患者的5个地方做了血清流行病学调查。发现了至少两种宿主动物——褐家鼠和黑线姬鼠。从丰南县一农村和唐山市郊两个农村捕捉的褐家鼠肺中检出了HFRS相关抗原、阳性率分别为18.9%、12.9%及16.1%。1981年10月份阳性率为18.5%,1982年3月份为15.5%。从黑线姬鼠肺中也检出此种抗原,阳性率为3.7%。褐家鼠HFRS抗体阳性率为17.9%。8例患者恢复期血清全与自制的褐家鼠肺HFRS抗原及KHF抗原发生高滴度抗体反应,前者1:2560~1:10240,后者>1:40或>1:1280。而1份急性期血清为阴性(<1:40)。从已经自鼠中检出HFRS抗原村的健康人取血396份,2份测到低滴度抗体(1:20及1:160);而从尚未自鼠中检出这种抗原的村,取健康人血179份,抗体全阴性。 |
| English Abstract: |
Eight cases of haemorrhagic fever with renal syndrome(HFRS) have been reported in Hebei Province since Nov. 1980. Seroepidemiological survays were carried out with indirect immunofluorescent antibody(IFA) and IFA inhibition tests at five places where HFRS cases had been found.
Two kinds of rodent reservoir were found, i.e. R.norvegicus and A. agrarius. HFRS relative antigen was detected in the lungs of R. norvegicus captured in a village of Fengnan County and two villages of Tangshan suburbs and the percentage of the rat carrying the antigen was 18.9%, 12.9% and 16.1% respectively. The rate of antigen carrier was 18.5% in Oct. 1981, and 15.5% in March 1982. This antigen was also found in the lungs of A. agrarius and the rate antigen carrier was 3.7%. 17.9% of R. norvegicus tested had HFRS antibody. All convalescent serum samples of 8 patients reacted at high titer with the antigen made from the HFRS positive lungs of R. norvegicus(1:2560-1:10240) and with the KHF antigen (>1:40 or > 1:1280). Whereas a sample taken at acute stage gave no reaction at 1:40 dilution, of 396 serum samples collected from the healthy person living at the village where the antigen had been found in rodent only 2 gave low antibody titer（1:20 and 1:160). All of 179 serum samples collected from the healthy person in the village where the antigen had not been found were negative. |
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