| 李雪翔,胡礼文,王仁宏,蔡长明.地鼠肾组织培养狂犬病疫苗预防性接种的血清学效果观察[J].Chinese journal of Epidemiology,1984,5(4):216-218 |
| 地鼠肾组织培养狂犬病疫苗预防性接种的血清学效果观察 |
| A Serological Study of Primary Hamster Kidney Cell Cultured Vaccine |
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| Abstract: |
| 地鼠肾组织培养狂犬病疫苗7针组（0、1、2、3、7、14及30天）的抗体应答较5针组（0、3、7、14及30天）为优。7针组在首针后14天狂犬病抗体≥1：40者为75.0%，且可维持半年。5针组则为50%，持续时间亦较短。感染后预防接种肾苗者应选择7针组免疫程序，并应定期加强，隔2~4个月加强一针，连续1~2年为好。 |
| English Abstract: |
| A Primary Hamster Kidney Cell Culture Vaccine (PHKV) was evaluted for the immune response to 7 doses and 5 doses in pre-exposured persons. The 7 doses of PHKV were given on days 0, 1, 2, 3, 7, 14 and 30, and 5 doses on days 0, 3, 7, 14 and 30.By day 14, 24 out of 32 persons injected (75.0%) in the 7 dose group and 15 out of 30 (50.0%) in the 5 dose group developed neutralizing antibodies higher than 1:40 (P<0.05). The peak titers in both groups were noted on day 45. The antibodies in the 7 dose group persisted for at least six months, longer than those of the 5 dose group.The result suggested that the 7-dose method was better than the 5 dose method for post-exposure prophy-laxis.Both groups must be given a booster dose every 2~4 months for 1~2 years after the first injection. |
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