| 王海涛,蒋豫图.HBV血清学标记及其滴度在人群中的若干特征[J].Chinese journal of Epidemiology,1985,6(5):269-272 |
| HBV血清学标记及其滴度在人群中的若干特征 |
| Some Characteristics of HBV Serological Markers and Their Titers in a Rural Population |
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| Abstract: |
| 用敏感的SPRIA和ELISA在一个生产队检测了HBV标记及其滴度。491人中HIBV总感染率52.3%(257/491),性别间无显著差异。HBV感染者中绝大多数(84%)为恢复期者。14%有HBsAg (无论有否抗-HBc),为现在感染者。15岁以下儿童和抗-HBe阳性者的抗-HBs滴度分别高于成人和抗-HBe阴性者。抗-HBs和抗-HBc均阳性者的抗-HBs滴度高于那些单独抗-HBs阳性者。提示抗-HBs滴度与检测时间早晚有关。不同年龄组的抗-HBc滴度无差异。抗-HBs和抗-HBc均阳性者的抗-HBc滴度与单独抗-HBc阳性者相似。这表明抗HBc滴度比抗-HBs的稳定。有肝炎病史者的抗-HBs和抗-HBc滴度高于无病史者。15岁以下儿童的HBeAg阳性率显著高于成人,男性高于女性。抗-HBs和抗-HBc均阳性者的抗-HBe阳性率显著高于其余HBV标记组合者。单独抗-HBs阳性者中无一人抗-HBe阳性。 |
| English Abstract: |
| HBV serological markers and their titers in a rural population were studied; HBsAg, anti-HBs and anti-HBc were tested with solid-phase radioimmunoassay and HBeAg and anti-HBe with enzyme-iinked immunosorbent assay.The overall HBV infection rate was 52.3 percent in the population,without significant-difference between the males and the females. Majority of HBV-infected persons (86%) was those who had been infected in the past and recovered.Only 14% of persons having HBV markers showed HBsAg positivity with or without anti-HBc, indicating that they were still having HBV infection at the time of observation.There was no signifecant difference in the titers of anti-HBs and anti-HBc between two sexes.The titers of anti-HBs in the children under 15 years and in the anti-HBe positive individuals were higher than those in the adults and in the anti-HBe negative persons.The titers of anti-HBs among individuals who were having both anti-HBs and anti-HBc were higher than, those among persons who had anti-HBs alone.These findings suggested that the titers of anti-HBs was related to the time interval between the beginning of HBV infection and the study period. The anti-HBc titers were not different among individuals of different age groups. Its titers in individuals having anti-HBs and anti-HBc were similar to those in persons having anti-HBc alone. These data indicated that the anti-HBc titers was more stable than those of anti-HBs. The titers of anti-HBs and anti-HBc among persons with history of hepatitis were higher than those among persons without hepatitis history.The HBeAg positive rate of the children under 15 years was significantly higher than that of the adults and was higher in the males than in the females.The frequency of anti-HBe in persons who were both anti-HBs and anti-HBc positive was the highest among the four different combinations of HBV markers.None of individuals who were anti-HBs positive alone was positive for anti-HBe. |
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