| 张吕先,朱既明.甲1型流感病毒的抗原漂移[J].Chinese journal of Epidemiology,1985,6(5):273-276 |
| 甲1型流感病毒的抗原漂移 |
| A Study on Antigenic Drift of In fluenza A1 Virus |
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| Abstract: |
| 本研究对1977~1983年期间分离的新甲1型部分毒株之间。新甲1型毒株和老甲1型部分毒株之间,进行了抗原性状的分析,结果表明,1983年新甲,型出现了血凝素抗原性状明显漂移的新变种株,其神经氨酸酶抗原虽有变异,但仍与近几年来流行的优势株相近,对此类毒株扩大流行的可能性进行了推测。对新老甲1型毒株间抗原分析的结果表明,流感病毒的抗原漂移无一定方向。在新甲1型变种中,不断出现老甲1型所没有的新抗原成分。这种趋向表明,甲1型流感可能不会在短期内自行消失。 |
| English Abstract: |
| In this paper, antigenic characterization of new influenza viruses isolated in 1977-1983 and comparison between new and old viruses were analysed. A new H1N1 isolate obtained in 1983 was found to be a significant drift in hemagglutinin, but its neuramidinase is close to recently prevailing strains. The epidemic potenttal of this strain was discussed. The result of antigenic analysis of the hemagglutinins of new and old H1N1 variants indicated that they had different courses of antigenic variation.New antigenic components not present in old H1N1 virus appeared continually in new H1N1 variants. These data indicate that H1N1 virus probably will not dissappear in the near future. |
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