| 庄辉,石有昌,于建国,柴庆元,刘明阳.甲型肝炎病人粪便排出甲肝病毒的规律[J].Chinese journal of Epidemiology,1986,7(1):1-3 |
| 甲型肝炎病人粪便排出甲肝病毒的规律 |
| A Study on the Rule of Hepatitis A Virus Sheded in Feces of Patients with Hepatitis A |
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| Abstract: |
| 本研究用EIA对62例甲肝病人的82份粪便进行了检测。发病前1~15天8份粪便,7份HAV阳性(87.50%),发病前16天以上2份粪便均为阴性。发病后1~7天阳性率为42.86%(6/14),8~15天为13.33%(6/45),16天以上13份,无一份阳性。对4名病人的19份系列粪便标本检测HAV表明,发病前1~15天粪便中HAV滴度最高(P/N=16.2±0.60),发病后急剧下降,至发病后第2周刚刚高于EIA的灵敏度(P/N=4.1±0.78)。 |
| English Abstract: |
A total of 82 fecal specimens collected from 62 patients with hepatitis A were tested for HAV by enzyme-linked immunosorbent assay (ELISA).7 of 8 (87.50%) fecal specimens collected 1-15 days before illness were positive for HAV, whereas no HAV was detected in two specimens obtained more than 16 days before onset of disease. 42.86% (6/14) of fecal specimens collected within 1-7 days after appearance of symptoms contained HAV. In the second week after onset of disease 13.33% (6/45) of specimens had HAV, whereas none of 13 specimens obtained later than 16 days after illness was positive for HAV.
Detection of HAV in 19 serial stools collected from 4 patients revealed that the highest titer of HAV was in the specimens obtained 1-15 days before illness (P/N ratio of 16.2±0.60). The titer of HAV dramatically declined after onset. It was just above the sensitivity of the test in the second week after illness (P/N ratio of 4.1±0.78). |
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