A群脑膜炎奈瑟氏菌脂多糖抗原血清学分型的流行病学意义

胡绪敬; 王士明; 奚文龙; 曹元其; 杨功焕; 李显英; 张韶声; 许才华; 罗龙泽; 侯高隆; 李怀文; 周矗; 井良义; 陈德全; 魏仪贞; 庄肃慧; 方国辉; 康殿财

Abstract

胡绪敬,王士明,奚文龙,曹元其,杨功焕,李显英,张韶声,许才华,罗龙泽,侯高隆,李怀文,周矗,井良义,陈德全,魏仪贞,庄肃慧,方国辉,康殿财.A群脑膜炎奈瑟氏菌脂多糖抗原血清学分型的流行病学意义[J].Chinese journal of Epidemiology,1986,7(1):14-16

A群脑膜炎奈瑟氏菌脂多糖抗原血清学分型的流行病学意义

Epidemiological Significance of Lipopolysaccharide Serotyping in Neisseria Meningitidis Group A

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Author Name	Affiliation
Hu Xujing	中国预防医学中心流研所
王士明	中国预防医学中心流研所
奚文龙	中国预防医学中心流研所
曹元其	中国预防医学中心流研所
杨功焕	中国预防医学中心流研所
李显英	江西省卫生防疫站
张韶声	江西省卫生防疫站
许才华	四川省卫生防疫站
罗龙泽	四川省卫生防疫站
侯高隆	河北省卫生防疫站
李怀文	河北省卫生防疫站
周矗	安徽省卫生防疫站
井良义	安徽省卫生防疫站
陈德全	临沂地区卫生防疫站
魏仪贞	临沂地区卫生防疫站
庄肃慧	临沂地区卫生防疫站
方国辉	浙江省常山县卫生防疫站
康殿财	黑龙江省甘南县卫生防疫站

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Abstract:

从江西等省收集了A群脑膜炎奈瑟氏菌324株,应用我们所报道的分型方法可以将96.91%的菌株分成三个主要的脂多糖血清型。不同地区所收集的A群菌株脂多糖血清型的地区分布是不同的,病人与其密切接触者的菌株具有相同的脂多糖血清型,L₁₀型菌株的致病力较强,可以引起流脑流行。本文所述的分型方法操作简便,分型率高。因此,作者认为A群菌株脂多糖血清学分型具有一定的流行病学意义,此分型方法很适于流行病学调查。

English Abstract:

324 strains of Neisseria meningitidis group A were collected from Jiangxi and other provinces in China. 96.9 per cent of them could be dividedinto three main lipopolysaccharide (LPS) serotypes with the serotyping method revised by us. Distribution of LPS serotypes was distinct among the group-A strains collected from various parts of China, and LPS serotypes of group-A strains from the patients' close contacts seemed to be identical with those of patients. The strains of L10 serotype had higher pathogenicity and could cause the prevalence of epidemic cerebrospinal menigitis in China. The serotyping method described in this paper was simple and convenient to perform and it's positive rate was very high. Therefore, the authors think that LPS serotyping of the group-A strains possesses a definite epidemiological significance and the technique of serotyping is suitable for epidemiological investigation.

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